Low total cholesterol is associated with high total mortality in patients with coronary heart disease

S. Behar; E. Graff; H. Reicher-Reiss; V. Boyko; N. Benderly; A. Sholan; D. Brunner; Z. Schlesinger; A. Fridensohn; L. Reisin; J. Jafari; S. Sclarovsky; Y. Frideman; B. Ostfeld; E. Abinader; S. Rochfleish; T. Rosenfeid; S. Khalid; Y. Kishon; R. Rotzak; I. Zahavi; J. Vitrai; B. Pelled; J. Pardu; S. Laniado; L. Sherf; S. Braun; Y. Eschar; A. Caspi; A. Arditi; S. Botwin; D. David; D. Weisnenberg; N. Roguin; A. Glusman; W. Markiewicz; D. Motlak; A. Marmour; M. Flich; M. Zion; J. Balkin; B. Rabinowiz; E. Barasch; N. Kristal; N. Liel; G. Assmann; P. Bauer; S. Eisenberg; L. H. Kuller; J. Schoenberger; C. Almog; A. Battler; M. Zion; J. Agmon; Y. Bar-Yehuda; S. Behar; D. Brunner; U. Goldbourt; E. Kaplinsky; L. Mandelzweig; H. Reicher-Reiss; S. Schwartz; J. Waysbort; S. Heimstra; E. Heyman

doi:10.1093/oxfordjournals.eurheartj.a015117

Low total cholesterol is associated with high total mortality in patients with coronary heart disease

S. Behar, E. Graff, H. Reicher-Reiss, V. Boyko, N. Benderly, A. Sholan, D. Brunner, Z. Schlesinger, A. Fridensohn, L. Reisin, J. Jafari, S. Sclarovsky, Y. Frideman, B. Ostfeld, E. Abinader, S. Rochfleish, T. Rosenfeid, S. Khalid, Y. Kishon, R. RotzakI. Zahavi, J. Vitrai, B. Pelled, J. Pardu, S. Laniado, L. Sherf, S. Braun, Y. Eschar, A. Caspi, A. Arditi, S. Botwin, D. David, D. Weisnenberg, N. Roguin, A. Glusman, W. Markiewicz, D. Motlak, A. Marmour, M. Flich, M. Zion, J. Balkin, B. Rabinowiz, E. Barasch, N. Kristal, N. Liel, G. Assmann, P. Bauer, S. Eisenberg, L. H. Kuller, J. Schoenberger, C. Almog, A. Battler, M. Zion, J. Agmon, Y. Bar-Yehuda, S. Behar, D. Brunner, U. Goldbourt, E. Kaplinsky, L. Mandelzweig, H. Reicher-Reiss, S. Schwartz, J. Waysbort, S. Heimstra, E. Heyman

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

The present non-intervention screening study was undertaken to explore the relationships between pre-existing low total cholesterol and all-cause mortality. Eleven thousand, five hundred and sixty-three patients with coronary heart disease who attended a screening visit but were not included in the Bezafibrate Infarction Prevention study were followed-up for a mean of 33 years after determination of baseline total cholesterol. Five hundred and ninety-five (5%) of this largely unselected population who had total cholesterol levels ≤ 160 mg.dl^-1 formed the study population. The remaining 10 968 patients acted as controls. The relative risk of all-cause mortality among patients with low cholesterol compared to others was 1.49 (95% CI: 1.16-1.91). The relative risk of non-cardiac death was 2.27 times higher in the low cholesterol group than in the controls (95% CI: 1.49-3.45), whereas the risk of cardiac death was the same in both groups (relative risk 1.09; 95% CI: 0.76-1.56). The most frequent cause of non-cardiac death associated with low total cholesterol was cancer. These results in patients with coronary heart disease add weight to previous studies associating low total cholesterol with an increased risk of non-cardiac death. However, a longer follow-up of this cohort of patients is necessary in order to clarify this association.

Original language	English
Pages (from-to)	52-59
Number of pages	8
Journal	European Heart Journal
Volume	18
Issue number	1
DOIs	https://doi.org/10.1093/oxfordjournals.eurheartj.a015117
State	Published - 1 Jan 1997
Externally published	Yes

Keywords

Cardiac mortality
Coronary heart disease
Non-cardiac mortality
Total cholesterol

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/oxfordjournals.eurheartj.a015117

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Behar, S., Graff, E., Reicher-Reiss, H., Boyko, V., Benderly, N., Sholan, A., Brunner, D., Schlesinger, Z., Fridensohn, A., Reisin, L., Jafari, J., Sclarovsky, S., Frideman, Y., Ostfeld, B., Abinader, E., Rochfleish, S., Rosenfeid, T., Khalid, S., Kishon, Y., ... Heyman, E. (1997). Low total cholesterol is associated with high total mortality in patients with coronary heart disease. European Heart Journal, 18(1), 52-59. https://doi.org/10.1093/oxfordjournals.eurheartj.a015117

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title = "Low total cholesterol is associated with high total mortality in patients with coronary heart disease",

abstract = "The present non-intervention screening study was undertaken to explore the relationships between pre-existing low total cholesterol and all-cause mortality. Eleven thousand, five hundred and sixty-three patients with coronary heart disease who attended a screening visit but were not included in the Bezafibrate Infarction Prevention study were followed-up for a mean of 33 years after determination of baseline total cholesterol. Five hundred and ninety-five (5%) of this largely unselected population who had total cholesterol levels ≤ 160 mg.dl-1 formed the study population. The remaining 10 968 patients acted as controls. The relative risk of all-cause mortality among patients with low cholesterol compared to others was 1.49 (95% CI: 1.16-1.91). The relative risk of non-cardiac death was 2.27 times higher in the low cholesterol group than in the controls (95% CI: 1.49-3.45), whereas the risk of cardiac death was the same in both groups (relative risk 1.09; 95% CI: 0.76-1.56). The most frequent cause of non-cardiac death associated with low total cholesterol was cancer. These results in patients with coronary heart disease add weight to previous studies associating low total cholesterol with an increased risk of non-cardiac death. However, a longer follow-up of this cohort of patients is necessary in order to clarify this association.",

keywords = "Cardiac mortality, Coronary heart disease, Non-cardiac mortality, Total cholesterol",

author = "S. Behar and E. Graff and H. Reicher-Reiss and V. Boyko and N. Benderly and A. Sholan and D. Brunner and Z. Schlesinger and A. Fridensohn and L. Reisin and J. Jafari and S. Sclarovsky and Y. Frideman and B. Ostfeld and E. Abinader and S. Rochfleish and T. Rosenfeid and S. Khalid and Y. Kishon and R. Rotzak and I. Zahavi and J. Vitrai and B. Pelled and J. Pardu and S. Laniado and L. Sherf and S. Braun and Y. Eschar and A. Caspi and A. Arditi and S. Botwin and D. David and D. Weisnenberg and N. Roguin and A. Glusman and W. Markiewicz and D. Motlak and A. Marmour and M. Flich and M. Zion and J. Balkin and B. Rabinowiz and E. Barasch and N. Kristal and N. Liel and G. Assmann and P. Bauer and S. Eisenberg and Kuller, {L. H.} and J. Schoenberger and C. Almog and A. Battler and M. Zion and J. Agmon and Y. Bar-Yehuda and S. Behar and D. Brunner and U. Goldbourt and E. Kaplinsky and L. Mandelzweig and H. Reicher-Reiss and S. Schwartz and J. Waysbort and S. Heimstra and E. Heyman",

year = "1997",

month = jan,

day = "1",

doi = "10.1093/oxfordjournals.eurheartj.a015117",

language = "English",

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pages = "52--59",

journal = "European Heart Journal",

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Behar, S, Graff, E, Reicher-Reiss, H, Boyko, V, Benderly, N, Sholan, A, Brunner, D, Schlesinger, Z, Fridensohn, A, Reisin, L, Jafari, J, Sclarovsky, S, Frideman, Y, Ostfeld, B, Abinader, E, Rochfleish, S, Rosenfeid, T, Khalid, S, Kishon, Y, Rotzak, R, Zahavi, I, Vitrai, J, Pelled, B, Pardu, J, Laniado, S, Sherf, L, Braun, S, Eschar, Y, Caspi, A, Arditi, A, Botwin, S, David, D, Weisnenberg, D, Roguin, N, Glusman, A, Markiewicz, W, Motlak, D, Marmour, A, Flich, M, Zion, M, Balkin, J, Rabinowiz, B, Barasch, E, Kristal, N, Liel, N, Assmann, G, Bauer, P, Eisenberg, S, Kuller, LH, Schoenberger, J, Almog, C, Battler, A, Zion, M, Agmon, J, Bar-Yehuda, Y, Behar, S, Brunner, D, Goldbourt, U, Kaplinsky, E, Mandelzweig, L, Reicher-Reiss, H, Schwartz, S, Waysbort, J, Heimstra, S & Heyman, E 1997, 'Low total cholesterol is associated with high total mortality in patients with coronary heart disease', European Heart Journal, vol. 18, no. 1, pp. 52-59. https://doi.org/10.1093/oxfordjournals.eurheartj.a015117

TY - JOUR

T1 - Low total cholesterol is associated with high total mortality in patients with coronary heart disease

AU - Behar, S.

AU - Graff, E.

AU - Reicher-Reiss, H.

AU - Boyko, V.

AU - Benderly, N.

AU - Sholan, A.

AU - Brunner, D.

AU - Schlesinger, Z.

AU - Fridensohn, A.

AU - Reisin, L.

AU - Jafari, J.

AU - Sclarovsky, S.

AU - Frideman, Y.

AU - Ostfeld, B.

AU - Abinader, E.

AU - Rochfleish, S.

AU - Rosenfeid, T.

AU - Khalid, S.

AU - Kishon, Y.

AU - Rotzak, R.

AU - Zahavi, I.

AU - Vitrai, J.

AU - Pelled, B.

AU - Pardu, J.

AU - Laniado, S.

AU - Sherf, L.

AU - Braun, S.

AU - Eschar, Y.

AU - Caspi, A.

AU - Arditi, A.

AU - Botwin, S.

AU - David, D.

AU - Weisnenberg, D.

AU - Roguin, N.

AU - Glusman, A.

AU - Markiewicz, W.

AU - Motlak, D.

AU - Marmour, A.

AU - Flich, M.

AU - Zion, M.

AU - Balkin, J.

AU - Rabinowiz, B.

AU - Barasch, E.

AU - Kristal, N.

AU - Liel, N.

AU - Assmann, G.

AU - Bauer, P.

AU - Eisenberg, S.

AU - Kuller, L. H.

AU - Schoenberger, J.

AU - Almog, C.

AU - Battler, A.

AU - Zion, M.

AU - Agmon, J.

AU - Bar-Yehuda, Y.

AU - Behar, S.

AU - Brunner, D.

AU - Goldbourt, U.

AU - Kaplinsky, E.

AU - Mandelzweig, L.

AU - Reicher-Reiss, H.

AU - Schwartz, S.

AU - Waysbort, J.

AU - Heimstra, S.

AU - Heyman, E.

PY - 1997/1/1

Y1 - 1997/1/1

N2 - The present non-intervention screening study was undertaken to explore the relationships between pre-existing low total cholesterol and all-cause mortality. Eleven thousand, five hundred and sixty-three patients with coronary heart disease who attended a screening visit but were not included in the Bezafibrate Infarction Prevention study were followed-up for a mean of 33 years after determination of baseline total cholesterol. Five hundred and ninety-five (5%) of this largely unselected population who had total cholesterol levels ≤ 160 mg.dl-1 formed the study population. The remaining 10 968 patients acted as controls. The relative risk of all-cause mortality among patients with low cholesterol compared to others was 1.49 (95% CI: 1.16-1.91). The relative risk of non-cardiac death was 2.27 times higher in the low cholesterol group than in the controls (95% CI: 1.49-3.45), whereas the risk of cardiac death was the same in both groups (relative risk 1.09; 95% CI: 0.76-1.56). The most frequent cause of non-cardiac death associated with low total cholesterol was cancer. These results in patients with coronary heart disease add weight to previous studies associating low total cholesterol with an increased risk of non-cardiac death. However, a longer follow-up of this cohort of patients is necessary in order to clarify this association.

AB - The present non-intervention screening study was undertaken to explore the relationships between pre-existing low total cholesterol and all-cause mortality. Eleven thousand, five hundred and sixty-three patients with coronary heart disease who attended a screening visit but were not included in the Bezafibrate Infarction Prevention study were followed-up for a mean of 33 years after determination of baseline total cholesterol. Five hundred and ninety-five (5%) of this largely unselected population who had total cholesterol levels ≤ 160 mg.dl-1 formed the study population. The remaining 10 968 patients acted as controls. The relative risk of all-cause mortality among patients with low cholesterol compared to others was 1.49 (95% CI: 1.16-1.91). The relative risk of non-cardiac death was 2.27 times higher in the low cholesterol group than in the controls (95% CI: 1.49-3.45), whereas the risk of cardiac death was the same in both groups (relative risk 1.09; 95% CI: 0.76-1.56). The most frequent cause of non-cardiac death associated with low total cholesterol was cancer. These results in patients with coronary heart disease add weight to previous studies associating low total cholesterol with an increased risk of non-cardiac death. However, a longer follow-up of this cohort of patients is necessary in order to clarify this association.

KW - Cardiac mortality

KW - Coronary heart disease

KW - Non-cardiac mortality

KW - Total cholesterol

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U2 - 10.1093/oxfordjournals.eurheartj.a015117

DO - 10.1093/oxfordjournals.eurheartj.a015117

M3 - Article

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AN - SCOPUS:0031052685

SN - 0195-668X

VL - 18

SP - 52

EP - 59

JO - European Heart Journal

JF - European Heart Journal

IS - 1

ER -

Low total cholesterol is associated with high total mortality in patients with coronary heart disease

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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