LTP Revisited: Reconsidering the Explanatory Power of Synaptic Efficacy

Jonathan Najenson

doi:10.1007/s13164-023-00694-w

LTP Revisited: Reconsidering the Explanatory Power of Synaptic Efficacy

Jonathan Najenson

Research output: Contribution to journal › Article › peer-review

Abstract

Changes in synaptic strength are described as a unifying hypothesis for memory formation and storage, leading philosophers to consider the ‘synaptic efficacy hypothesis’ as a paradigmatic explanation in neuroscience. Craver’s mosaic view has been influential in understanding synaptic efficacy by presenting long-term potentiation as a multi-level mechanism nested within a multi-level structure. This paper argues that the mosaic view fails to fully capture the explanatory power of the synaptic efficacy hypothesis due to assumptions about multi-level mechanisms. I present an alternative approach that emphasizes the explanatory function of unification, accounting for the widespread consensus in neuroscience regarding synaptic efficacy by highlighting the stability of synaptic causal variables across different multi-level mechanisms.

Original language	English
Journal	Review of Philosophy and Psychology
DOIs	https://doi.org/10.1007/s13164-023-00694-w
State	Accepted/In press - 1 Jan 2023
Externally published	Yes

Keywords

Explanation
LTP
Mechanism
Memory
Synaptic Efficacy
Unification

ASJC Scopus subject areas

Experimental and Cognitive Psychology
Philosophy

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10.1007/s13164-023-00694-w

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abstract = "Changes in synaptic strength are described as a unifying hypothesis for memory formation and storage, leading philosophers to consider the {\textquoteleft}synaptic efficacy hypothesis{\textquoteright} as a paradigmatic explanation in neuroscience. Craver{\textquoteright}s mosaic view has been influential in understanding synaptic efficacy by presenting long-term potentiation as a multi-level mechanism nested within a multi-level structure. This paper argues that the mosaic view fails to fully capture the explanatory power of the synaptic efficacy hypothesis due to assumptions about multi-level mechanisms. I present an alternative approach that emphasizes the explanatory function of unification, accounting for the widespread consensus in neuroscience regarding synaptic efficacy by highlighting the stability of synaptic causal variables across different multi-level mechanisms.",

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AB - Changes in synaptic strength are described as a unifying hypothesis for memory formation and storage, leading philosophers to consider the ‘synaptic efficacy hypothesis’ as a paradigmatic explanation in neuroscience. Craver’s mosaic view has been influential in understanding synaptic efficacy by presenting long-term potentiation as a multi-level mechanism nested within a multi-level structure. This paper argues that the mosaic view fails to fully capture the explanatory power of the synaptic efficacy hypothesis due to assumptions about multi-level mechanisms. I present an alternative approach that emphasizes the explanatory function of unification, accounting for the widespread consensus in neuroscience regarding synaptic efficacy by highlighting the stability of synaptic causal variables across different multi-level mechanisms.

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LTP Revisited: Reconsidering the Explanatory Power of Synaptic Efficacy

Abstract

Keywords

ASJC Scopus subject areas

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