Lupus anticoagulant and anticardiolipin antibodies in systemic lupus erythematosus

S. Sukenik, A. El-Roeiy, Y. Shoenfeld

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The lupus anticoagulant (LA) is an acquired autoantibody of the IgG or IgM type that acts on platelet factor III, inhibiting the generation of the prothrombin activator complex. It is prevalent in 5-10% of SLE cases and, in contradistinction to the name anticoagulant, it may be associated with thrombotic events, recurrent abortion or intrauterine death. Anti-cardiolipin antibody like LA, is an anti-phospholipid antibody and also causes recurrent thrombotic events. Mention has been made of a possible cross-reactivity between anti-phospholipid antibodies and anti-DNA antibodies. The optimal treatment for this problem is at present unknown.

Original languageEnglish
Pages (from-to)86-89
Number of pages4
JournalActa Haematologica
Volume76
Issue number2-3
DOIs
StatePublished - 1 Jan 1986

Keywords

  • Anti-DNA antibodies
  • Anti-phospholipid antibodies
  • Anticoagulant
  • Autoantibodies
  • Systemic lupus erythematosus

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