Lymphangiogenesis in classical Hodgkin lymphoma - preliminary study with clinicopathological correlations

Daniel Benharroch, Isebrand Prinsloo, Jacob Gopas, Irena Lazarev

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


A role for lymphangiogenesis in metastatic breast and prostate cancers has been suggested recently. The relevance of lymphangiogenesis in cancer as a rule, and more specifically in classical Hodgkin lymphoma, is poorly understood in comparison with that of angiogenesis. In a preliminary (pilot) study we have investigated the role of lymphatic vessels growth in 19 cases of classical Hodgkin lymphoma stained with the D2-40 (podoplanin) antibody. In each case, three lymphatic vessels hot spots were scrutinized twice. Of the 57 hot spots thus identified, we chose 15 at random for photography, microvessel counting and image analysis. We determined the mean perimeter, surface area, major axis length and complexity factor for each hot spot and correlated them with clinical and biological features of classical Hodgkin lymphoma. No correlations were found with clinical features. No associations were noted with the standard immuno-markers of classical Hodgkin lymphoma. However, significant inverse correlations were shown with pRb, BAX and IκB-α expression. The mean lymphatic major axis length was inversely correlated with the complexity factor. Last, we carried out an additional clinicopathological correlation of the expression of pRb, BAX and IκB-α in a cohort of classical Hodgkin lymphoma patients previously published.

Original languageEnglish
Pages (from-to)2117-2123
Number of pages7
JournalJournal of Cancer
Issue number14
StatePublished - 1 Jan 2016


  • BAX
  • Classical Hodgkin lymphoma
  • Complexity factor
  • IκB α
  • Lymphatic vessels
  • PRb

ASJC Scopus subject areas

  • Oncology


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