Lymphocyte G-protein receptor kinase (GRK)3 mRNA levels in bipolar disorder

Galit Shaltiel, Alon Shamir, Itzhak Levi, Yuly Bersudsky, Galila Agam

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Linkage studies in bipolar disorder were positive for markers in the region of chromosome 22q12.1 including the gene coding for G-protein receptor kinase (GRK)3. Two of six variants of the GRK3 5′-UTR/promoter were reported to be associated with bipolar disorder. GRK3 protein levels in lymphoblastoid cell lines derived from bipolar patients originating from families with linkage to chromosome 22q11 were reported to be decreased compared to those of control subjects and correlated with disease severity. We compared GRK3 mRNA levels in fresh lymphocytes from 31 bipolar patients vs. 26 control subjects, using real-time RT-PCR. No overall difference was found between patients and controls. However, GRK3 mRNA levels were markedly and significantly reduced in the subgroup of patients with no family history of a major psychiatric disorder compared with patients with family history.

Original languageEnglish
Pages (from-to)761-766
Number of pages6
JournalInternational Journal of Neuropsychopharmacology
Volume9
Issue number6
DOIs
StatePublished - 1 Dec 2006

Keywords

  • Bipolar disorder
  • Fresh lymphocytes
  • G-protein coupled receptor kinase (GRK)3
  • mRNA

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