TY - JOUR
T1 - Lymphvascular space involvement compromises the survival of patients with stage I endometrial cancer
T2 - Results of a multicenter study
AU - Gemer, O.
AU - Ben Arie, A.
AU - Levy, T.
AU - Gdalevich, M.
AU - Lorian, M.
AU - Barak, F.
AU - Anteby, E.
AU - Lavie, O.
PY - 2007/6/1
Y1 - 2007/6/1
N2 - Aims: To quantify the relative risk associated with lymphvascular space involvement (LVSI) on outcome measures in patients with apparent stage I endometrial cancer. Methods: Six hundred and ninety nine consecutive patients with endometrial carcinoma apparent stage I, who underwent surgery in one of four gynecological oncology centers in Israel, comprised the study population. Forty cases with and 659 without LVSI were followed for a median time of 39 months. Recurrence free, disease specific and overall survival was compared between the two groups. The effect of LVSI, adjusted for other clinical and histo-pathological prognostic factors, was assessed by multivariate analysis. Results: The univariate Kaplan-Meier procedure for survival analysis showed that patients with LVSI had lower recurrence free survival (p = 0.0003), worse disease specific (p = 0.0007) and overall survival (p < 0.0001). Cox proportional hazards model demonstrated a trend toward shorter recurrence free survival (HR = 2.0, 95% CI 0.9, 4.5; p = 0.08), a worse disease specific survival (HR = 2.8, 95% CI 1.1, 7.4; p = 0.04) and decreased overall survival (HR = 2.0, 95% CI 1.1, 3.8; p = 0.03) in cases with LVSI. Conclusions: In patients with apparent stage I endometrial cancer the presence of LVSI, an independent poor prognostic factor, is associated with a two fold increased risk of death. The presence of LVSI warrants consideration when deciding upon post operative management.
AB - Aims: To quantify the relative risk associated with lymphvascular space involvement (LVSI) on outcome measures in patients with apparent stage I endometrial cancer. Methods: Six hundred and ninety nine consecutive patients with endometrial carcinoma apparent stage I, who underwent surgery in one of four gynecological oncology centers in Israel, comprised the study population. Forty cases with and 659 without LVSI were followed for a median time of 39 months. Recurrence free, disease specific and overall survival was compared between the two groups. The effect of LVSI, adjusted for other clinical and histo-pathological prognostic factors, was assessed by multivariate analysis. Results: The univariate Kaplan-Meier procedure for survival analysis showed that patients with LVSI had lower recurrence free survival (p = 0.0003), worse disease specific (p = 0.0007) and overall survival (p < 0.0001). Cox proportional hazards model demonstrated a trend toward shorter recurrence free survival (HR = 2.0, 95% CI 0.9, 4.5; p = 0.08), a worse disease specific survival (HR = 2.8, 95% CI 1.1, 7.4; p = 0.04) and decreased overall survival (HR = 2.0, 95% CI 1.1, 3.8; p = 0.03) in cases with LVSI. Conclusions: In patients with apparent stage I endometrial cancer the presence of LVSI, an independent poor prognostic factor, is associated with a two fold increased risk of death. The presence of LVSI warrants consideration when deciding upon post operative management.
KW - Endometrial cancer
KW - Lymphvascular space involvement
KW - Survival
UR - http://www.scopus.com/inward/record.url?scp=34248566806&partnerID=8YFLogxK
U2 - 10.1016/j.ejso.2007.01.009
DO - 10.1016/j.ejso.2007.01.009
M3 - Article
C2 - 17317084
AN - SCOPUS:34248566806
SN - 0748-7983
VL - 33
SP - 644
EP - 647
JO - European Journal of Surgical Oncology
JF - European Journal of Surgical Oncology
IS - 5
ER -
