Lysine methylation signaling of non-histone proteins in the nucleus

Research output: Contribution to journalReview articlepeer-review

37 Scopus citations


Lysine methylation, catalyzed by protein lysine methyltransferases (PKMTs), is a central post-translational modification regulating many signaling pathways. It has direct and indirect effects on chromatin structure and transcription. Accumulating evidence suggests that dysregulation of PKMT activity has a fundamental impact on the development of many pathologies. While most of these works involve in-depth analysis of methylation events in the context of histones, in recent years, it has become evident that methylation of non-histone proteins also plays a pivotal role in cell processes. This review highlights the importance of non-histone methylation, with focus on methylation events taking place in the nucleus. Known experimental platforms which were developed to identify new methylation events, as well as examples of specific lysine methylation signaling events which regulate key transcription factors, are presented. In addition, the role of these methylation events in normal and disease states is emphasized.

Original languageEnglish
Pages (from-to)2873-2883
Number of pages11
JournalCellular and Molecular Life Sciences
Issue number15
StatePublished - 1 Aug 2019


  • Lysine methylation
  • Methylation signaling
  • Non-histone methylation
  • Post-translational modifications (PTMs)
  • Protein lysine methyltransferases (PKMTs)

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology


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