Macromolecular Nano-Assemblies for Enhancing the Effect of Oxygen-Dependent Photodynamic Therapy Against Hypoxic Tumors

Peipei Zhang; Meng Cheng; Yael Levi-Kalisman; Uri Raviv; Yichun Xu; Junsong Han; Hongjing Dou

doi:10.1002/chem.202401700

Macromolecular Nano-Assemblies for Enhancing the Effect of Oxygen-Dependent Photodynamic Therapy Against Hypoxic Tumors

Peipei Zhang, Meng Cheng, Yael Levi-Kalisman, Uri Raviv, Yichun Xu, Junsong Han, Hongjing Dou

Research output: Contribution to journal › Review article › peer-review

Abstract

In oxygen (O₂)-dependent photodynamic therapy (PDT), photosensitizers absorb light energy, which is then transferred to ambient O₂ and subsequently generates cytotoxic singlet oxygen (¹O₂). Therefore, the availability of O₂ and the utilization efficiency of generated ¹O₂ are two significant factors that influence the effectiveness of PDT. However, tumor microenvironments (TMEs) characterized by hypoxia and limited utilization efficiency of ¹O₂ resulting from its short half-life and short diffusion distance significantly restrict the applicability of PDT for hypoxic tumors. To address these challenges, numerous macromolecular nano-assemblies (MNAs) have been designed to relieve hypoxia, utilize hypoxia or enhance the utilization efficiency of ¹O₂. Herein, we provide a comprehensive review on recent advancements achieved with MNAs in enhancing the effectiveness of O₂-dependent PDT against hypoxic tumors.

Original language	English
Journal	Chemistry - A European Journal
DOIs	https://doi.org/10.1002/chem.202401700
State	Accepted/In press - 1 Jan 2024
Externally published	Yes

Keywords

Hypoxic tumors
Macromolecule
Nanostructures
O-dependent photodynamic therapy
Self-assembly

ASJC Scopus subject areas

Catalysis
General Chemistry
Organic Chemistry

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10.1002/chem.202401700

Cite this

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title = "Macromolecular Nano-Assemblies for Enhancing the Effect of Oxygen-Dependent Photodynamic Therapy Against Hypoxic Tumors",

abstract = "In oxygen (O2)-dependent photodynamic therapy (PDT), photosensitizers absorb light energy, which is then transferred to ambient O2 and subsequently generates cytotoxic singlet oxygen (1O2). Therefore, the availability of O2 and the utilization efficiency of generated 1O2 are two significant factors that influence the effectiveness of PDT. However, tumor microenvironments (TMEs) characterized by hypoxia and limited utilization efficiency of 1O2 resulting from its short half-life and short diffusion distance significantly restrict the applicability of PDT for hypoxic tumors. To address these challenges, numerous macromolecular nano-assemblies (MNAs) have been designed to relieve hypoxia, utilize hypoxia or enhance the utilization efficiency of 1O2. Herein, we provide a comprehensive review on recent advancements achieved with MNAs in enhancing the effectiveness of O2-dependent PDT against hypoxic tumors.",

keywords = "Hypoxic tumors, Macromolecule, Nanostructures, O-dependent photodynamic therapy, Self-assembly",

author = "Peipei Zhang and Meng Cheng and Yael Levi-Kalisman and Uri Raviv and Yichun Xu and Junsong Han and Hongjing Dou",

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doi = "10.1002/chem.202401700",

language = "English",

journal = "Chemistry - A European Journal",

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T1 - Macromolecular Nano-Assemblies for Enhancing the Effect of Oxygen-Dependent Photodynamic Therapy Against Hypoxic Tumors

AU - Zhang, Peipei

AU - Cheng, Meng

AU - Levi-Kalisman, Yael

AU - Raviv, Uri

AU - Xu, Yichun

AU - Han, Junsong

AU - Dou, Hongjing

PY - 2024/1/1

Y1 - 2024/1/1

N2 - In oxygen (O2)-dependent photodynamic therapy (PDT), photosensitizers absorb light energy, which is then transferred to ambient O2 and subsequently generates cytotoxic singlet oxygen (1O2). Therefore, the availability of O2 and the utilization efficiency of generated 1O2 are two significant factors that influence the effectiveness of PDT. However, tumor microenvironments (TMEs) characterized by hypoxia and limited utilization efficiency of 1O2 resulting from its short half-life and short diffusion distance significantly restrict the applicability of PDT for hypoxic tumors. To address these challenges, numerous macromolecular nano-assemblies (MNAs) have been designed to relieve hypoxia, utilize hypoxia or enhance the utilization efficiency of 1O2. Herein, we provide a comprehensive review on recent advancements achieved with MNAs in enhancing the effectiveness of O2-dependent PDT against hypoxic tumors.

AB - In oxygen (O2)-dependent photodynamic therapy (PDT), photosensitizers absorb light energy, which is then transferred to ambient O2 and subsequently generates cytotoxic singlet oxygen (1O2). Therefore, the availability of O2 and the utilization efficiency of generated 1O2 are two significant factors that influence the effectiveness of PDT. However, tumor microenvironments (TMEs) characterized by hypoxia and limited utilization efficiency of 1O2 resulting from its short half-life and short diffusion distance significantly restrict the applicability of PDT for hypoxic tumors. To address these challenges, numerous macromolecular nano-assemblies (MNAs) have been designed to relieve hypoxia, utilize hypoxia or enhance the utilization efficiency of 1O2. Herein, we provide a comprehensive review on recent advancements achieved with MNAs in enhancing the effectiveness of O2-dependent PDT against hypoxic tumors.

KW - Hypoxic tumors

KW - Macromolecule

KW - Nanostructures

KW - O-dependent photodynamic therapy

KW - Self-assembly

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DO - 10.1002/chem.202401700

M3 - Review article

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SN - 0947-6539

JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

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Macromolecular Nano-Assemblies for Enhancing the Effect of Oxygen-Dependent Photodynamic Therapy Against Hypoxic Tumors

Abstract

Keywords

ASJC Scopus subject areas

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