Macrophage Migration Inhibition Factor (MIF) in Drug Eruption

Sima Halevy, Marcelo H. Grunwald, Miriam Sandbank, Bella Buimovice, Henry Joshua, Ella Livni

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

A controlled study was conducted to evaluate the macrophage migration inhibition factor test as a diagnostic aid in 50 patients with drug eruption. Two groups of patients served as controls: group A, 110 patients being treated with drugs without known cutaneous adverse reactions, and group B, 15 patients suffering from dermatologic disorders unrelated to drugs being taken. Positive macrophage migration inhibition factor responses were found toward a variety of drugs in 35 (70%) of the patients with drug eruptions, with no relation to the type of eruption or the duration of drug intake. The percentage of positive macrophage migration inhibition factor responses toward drugs in the patients with drug eruptions was higher than that in the two control groups (4.5% and 6.7%, respectively). The percentage of positive macrophage migration inhibition factor responses recorded for clinically “suspected” drugs was significantly higher than that recorded for the “nonsuspected” drugs.

Original languageEnglish
Pages (from-to)48-51
Number of pages4
JournalArchives of Dermatology
Volume126
Issue number1
DOIs
StatePublished - 1 Jan 1990

Fingerprint

Dive into the research topics of 'Macrophage Migration Inhibition Factor (MIF) in Drug Eruption'. Together they form a unique fingerprint.

Cite this