@inproceedings{7bdd0c5b4c83450595962fc71550a6f7,
title = "Magnetic cell therapy for vascular disease",
abstract = "The present study evaluated the potential of magnetically mediated delivery of endothelial cells (ECs) to inhibit in-stent stenosis induced by mechanical injury in a rat carotid artery stent angioplasty model. Syngeneic ECs loaded with biodegradable polymeric magnetic nanoparticles (MNPs) were administered at the distal end of the stented artery using a brief exposure (12 min) to a uniform magnetic field (1.4-kOe). After two months, magnetic delivery of ECs demonstrated significant protection from stenosis at the distal part of the stent in the cell therapy group compared to both the proximal part of stent in the cell therapy group and the control (stented, nontreated) group: 1.7-fold (p < 0.001) less reduction in lumen diameter as measured by B-mode and color Doppler ultrasound, 2.3-fold (p < 0.001) less reduction in the ratios of peak systolic velocities as measured by pulsed wave Doppler ultrasound, and 2.1-fold (p < 0.001) attenuation of stenosis as determined through end point morphometric analysis.",
keywords = "Cell therapy, Endothelium, In-stent restenosis, Magnetic targeting, Vascular healing",
author = "B. Polyak",
note = "Publisher Copyright: {\textcopyright} 2018 IEEE.; 2018 International Conference Laser Optics, ICLO 2018 ; Conference date: 04-06-2018 Through 08-06-2018",
year = "2018",
month = aug,
day = "13",
doi = "10.1109/LO.2018.8435663",
language = "English",
isbn = "9781538636121",
series = "Proceedings - International Conference Laser Optics 2018, ICLO 2018",
publisher = "Institute of Electrical and Electronics Engineers",
pages = "542",
booktitle = "Proceedings - International Conference Laser Optics 2018, ICLO 2018",
address = "United States",
}