Magnetic nanoparticle-based approaches to locally target therapy and enhance tissue regeneration in vivo

Richard Sensenig, Yulia Sapir, Cristin MacDonald, Smadar Cohen, Boris Polyak

Research output: Contribution to journalReview articlepeer-review

172 Scopus citations

Abstract

Magnetic-based systems utilizing superparamagnetic nanoparticles and a magnetic field gradient to exert a force on these particles have been used in a wide range of biomedical applications. This review is focused on drug targeting applications that require penetration of a cellular barrier as well as strategies to improve the efficacy of targeting in these biomedical applications. Another focus of this review is regenerative applications utilizing tissue engineered scaffolds prepared with the aid of magnetic particles, the use of remote actuation for release of bioactive molecules and magneto-mechanical cell stimulation, cell seeding and cell patterning.

Original languageEnglish
Pages (from-to)1425-1442
Number of pages18
JournalNanomedicine
Volume7
Issue number9
DOIs
StatePublished - 1 Sep 2012

Keywords

  • cell therapy
  • drug delivery
  • forced transport
  • magnetic cell seeding
  • magnetic cell stimulation
  • magnetic targeting
  • patterned cell assemblies
  • superparamagnetic nanoparticles
  • time-varied magnetic field
  • tissue engineering

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Materials Science (all)

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