Major adverse reactions to yeast-derived hepatitis B vaccines - A review

I. Grotto, Y. Mandel, M. Ephros, I. Ashkenazi, J. Shemer

Research output: Contribution to journalArticlepeer-review

61 Scopus citations


Yeast derived recombinant DNA hepatitis B vaccines used became widely accepted since the early 1990s. Severe adverse events have been reported infrequently in adults and rarely in infants and children given hepatitis B vaccine in the ten years which have passed since the introduction of the vaccine. Some of the data were summarized in previous review articles. Our review of the literature revealed reports of serious adverse reactions which included immediate reactions (anaphylaxis and urticaria) as well as delayed reactions, including skin, rheumatic, vasculitic (including Systemic Lupus Erythematosus and glumerulonephritis), hematologic, ophthalmologic and neurologic reactions. These cases were summarized and a pathogenetic mechanism is offered.

Original languageEnglish
Pages (from-to)329-334
Number of pages6
Issue number4
StatePublished - 1 Jan 1998


  • Adverse reactions
  • Hepatitis B vaccine
  • Review

ASJC Scopus subject areas

  • Molecular Medicine
  • General Immunology and Microbiology
  • General Veterinary
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases


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