Male fertility preservation–Methods, indications and challenges

Leonti Grin, Eliezer Girsh, Avi Harlev

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations


Male fertility preservation has been steadily increasing over the past two decades. Significant improvements have been achieved in the treatment modalities of cancer and other severe chronic medical conditions, leading to an increase in patient survivorship and the resulting demand for future parenthood. Recognition and proper patient counselling before commencing therapies with a potential gonadotoxic effect are of paramount importance. Similarly, nonmedically indicated fertility preservation is on the rise. Social sperm banking, gender dysphoria prior to affirmation procedures and posthumous reproduction preservation are becoming more common. When timing and logistics are appropriate, sperm cryopreservation is considered the gold standard for fertility preservation. Testicular tissue and spermatogonial stem cell autotransplantation is considered experimental and represents a promising alternative for pre-pubertal patients. The current paper aims to review the recent trends in male fertility preservation, the common indications for sperm cryopreservation, techniques for sperm retrieval and experimental frontiers.

Original languageEnglish
Article numbere13635
Issue number2
StatePublished - 1 Mar 2021


  • fertility preservation
  • male fertility
  • sperm banking
  • sperm cryopreservation

ASJC Scopus subject areas

  • Endocrinology
  • Urology


Dive into the research topics of 'Male fertility preservation–Methods, indications and challenges'. Together they form a unique fingerprint.

Cite this