Malignant melanoma of the nipple with autoamputation of the breast (Hebrew)

Malignant melanoma of the breast is rare and can occur as primary melanoma of the breast, metastatic malignant melanoma to the breast or malignant melanoma of the skin usually originating in the nipple. A patient is presented with malignant melanoma of the nipple which simulated the clinical appearance of advanced primary cancer of the breast with autoamputation. On diagnosis the patient had disseminated metastases to the bones, lungs and brain. Combined chemotherapy, which included oncovin, DOC and BCNU, was not effective and the patient died 2 mth after diagnosis. She had noticed changes in her breast about 5 yr prior to diagnosis, but although all during this period she was under medical care for hypertension, she never called these symptoms to the attention of her physician.