Manganese-grafted detonation nanodiamond, a novel potential MRI contrast agent

A. M. Panich; A. I. Shames; A. E. Aleksenskii; E. B. Yudina; A. Ya Vul'

doi:10.1016/j.diamond.2021.108590

Manganese-grafted detonation nanodiamond, a novel potential MRI contrast agent

A. M. Panich, A. I. Shames, A. E. Aleksenskii, E. B. Yudina, A. Ya Vul'

Department of Physics

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Aiming to develop versatile MRI contrast agents, we report on preparation and magnetic resonance study of a novel nanomaterial - detonation nanodiamond (DND) with manganese ions directly grafted to its surface. The sample was prepared by reacting an aqueous nanodiamond suspension with an aqueous solution of manganese sulfate. We present clear evidence on chemical binding of Mn²⁺ ions to nanodiamond surface; ions interact with electron and nuclear spins of a diamond nanoparticle, thus accelerating spin-lattice relaxation. The distance between Mn²⁺ ion and diamond surface was estimated from the ¹³C NMR relaxation data. Comparison of the interaction of Mn ions with DND to that in the recently studied Gd-grafted DND suggests that Mn-DND will be a potential material as an MRI contrast agent.

Original language	English
Article number	108590
Journal	Diamond and Related Materials
Volume	119
DOIs	https://doi.org/10.1016/j.diamond.2021.108590
State	Published - 1 Nov 2021

Keywords

Grafting
Manganese
Nanodiamond
Nuclear magnetic resonance
electron paramagnetic resonance

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
General Chemistry
Mechanical Engineering
Materials Chemistry
Electrical and Electronic Engineering

Access to Document

10.1016/j.diamond.2021.108590

Cite this

@article{35ef525c1af74832af43c0d87fc3e5fc,

title = "Manganese-grafted detonation nanodiamond, a novel potential MRI contrast agent",

abstract = "Aiming to develop versatile MRI contrast agents, we report on preparation and magnetic resonance study of a novel nanomaterial - detonation nanodiamond (DND) with manganese ions directly grafted to its surface. The sample was prepared by reacting an aqueous nanodiamond suspension with an aqueous solution of manganese sulfate. We present clear evidence on chemical binding of Mn2+ ions to nanodiamond surface; ions interact with electron and nuclear spins of a diamond nanoparticle, thus accelerating spin-lattice relaxation. The distance between Mn2+ ion and diamond surface was estimated from the 13C NMR relaxation data. Comparison of the interaction of Mn ions with DND to that in the recently studied Gd-grafted DND suggests that Mn-DND will be a potential material as an MRI contrast agent.",

keywords = "Grafting, Manganese, Nanodiamond, Nuclear magnetic resonance, electron paramagnetic resonance",

author = "Panich, {A. M.} and Shames, {A. I.} and Aleksenskii, {A. E.} and Yudina, {E. B.} and Vul', {A. Ya}",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier B.V.",

year = "2021",

month = nov,

day = "1",

doi = "10.1016/j.diamond.2021.108590",

language = "English",

volume = "119",

journal = "Diamond and Related Materials",

issn = "0925-9635",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Manganese-grafted detonation nanodiamond, a novel potential MRI contrast agent

AU - Panich, A. M.

AU - Shames, A. I.

AU - Aleksenskii, A. E.

AU - Yudina, E. B.

AU - Vul', A. Ya

PY - 2021/11/1

Y1 - 2021/11/1

N2 - Aiming to develop versatile MRI contrast agents, we report on preparation and magnetic resonance study of a novel nanomaterial - detonation nanodiamond (DND) with manganese ions directly grafted to its surface. The sample was prepared by reacting an aqueous nanodiamond suspension with an aqueous solution of manganese sulfate. We present clear evidence on chemical binding of Mn2+ ions to nanodiamond surface; ions interact with electron and nuclear spins of a diamond nanoparticle, thus accelerating spin-lattice relaxation. The distance between Mn2+ ion and diamond surface was estimated from the 13C NMR relaxation data. Comparison of the interaction of Mn ions with DND to that in the recently studied Gd-grafted DND suggests that Mn-DND will be a potential material as an MRI contrast agent.

AB - Aiming to develop versatile MRI contrast agents, we report on preparation and magnetic resonance study of a novel nanomaterial - detonation nanodiamond (DND) with manganese ions directly grafted to its surface. The sample was prepared by reacting an aqueous nanodiamond suspension with an aqueous solution of manganese sulfate. We present clear evidence on chemical binding of Mn2+ ions to nanodiamond surface; ions interact with electron and nuclear spins of a diamond nanoparticle, thus accelerating spin-lattice relaxation. The distance between Mn2+ ion and diamond surface was estimated from the 13C NMR relaxation data. Comparison of the interaction of Mn ions with DND to that in the recently studied Gd-grafted DND suggests that Mn-DND will be a potential material as an MRI contrast agent.

KW - Grafting

KW - Manganese

KW - Nanodiamond

KW - Nuclear magnetic resonance

KW - electron paramagnetic resonance

UR - http://www.scopus.com/inward/record.url?scp=85114385751&partnerID=8YFLogxK

U2 - 10.1016/j.diamond.2021.108590

DO - 10.1016/j.diamond.2021.108590

M3 - Article

AN - SCOPUS:85114385751

SN - 0925-9635

VL - 119

JO - Diamond and Related Materials

JF - Diamond and Related Materials

M1 - 108590

ER -

Manganese-grafted detonation nanodiamond, a novel potential MRI contrast agent

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this