TY - JOUR
T1 - Mangiferin in cancer chemoprevention and treatment
T2 - Pharmacokinetics and molecular targets
AU - Rajendran, Peramaiyan
AU - Rengarajan, Thamaraiselvan
AU - Nandakumar, Natarajan
AU - Divya, H.
AU - Nishigaki, Ikuo
N1 - Publisher Copyright:
© 2014 Informa Healthcare USA, Inc. All rights reserved.
PY - 2015/2/1
Y1 - 2015/2/1
N2 - A variety of bioactive food components have been shown to modulate inflammatory responses and to attenuate carcinogenesis. Polyphenols isolated several years ago from various medicinal plants now seem to have a prominent role in the prevention and therapy of a variety of ailments. Mangiferin, a unique, important, and highly investigated polyphenol, has attracted much attention of late for its potential as a chemopreventive and chemotherapeutic agent against various types of cancer. Mangiferin has been shown to target multiple proinflammatory transcription factors, cell-cycle proteins, growth factors, kinases, cytokines, chemokines, adhesion molecules, and inflammatory enzymes. These targets can potentially mediate the chemopreventive and therapeutic effects of mangiferin by inhibiting the initiation, promotion, and metastasis of cancer. This review not only summarizes the diverse molecular targets of mangiferin, but also gives the results of various preclinical studies that have been performed in the last decade with this promising polyphenol.
AB - A variety of bioactive food components have been shown to modulate inflammatory responses and to attenuate carcinogenesis. Polyphenols isolated several years ago from various medicinal plants now seem to have a prominent role in the prevention and therapy of a variety of ailments. Mangiferin, a unique, important, and highly investigated polyphenol, has attracted much attention of late for its potential as a chemopreventive and chemotherapeutic agent against various types of cancer. Mangiferin has been shown to target multiple proinflammatory transcription factors, cell-cycle proteins, growth factors, kinases, cytokines, chemokines, adhesion molecules, and inflammatory enzymes. These targets can potentially mediate the chemopreventive and therapeutic effects of mangiferin by inhibiting the initiation, promotion, and metastasis of cancer. This review not only summarizes the diverse molecular targets of mangiferin, but also gives the results of various preclinical studies that have been performed in the last decade with this promising polyphenol.
KW - Cancer
KW - Chemoprevention
KW - Inflammation
KW - Mangiferin
KW - Polyphenol
UR - http://www.scopus.com/inward/record.url?scp=84925778141&partnerID=8YFLogxK
U2 - 10.3109/10799893.2014.931431
DO - 10.3109/10799893.2014.931431
M3 - Article
C2 - 24984103
AN - SCOPUS:84925778141
SN - 1079-9893
VL - 35
SP - 76
EP - 84
JO - Journal of Receptor and Signal Transduction Research
JF - Journal of Receptor and Signal Transduction Research
IS - 1
ER -