Mangiferin in cancer chemoprevention and treatment: Pharmacokinetics and molecular targets

Peramaiyan Rajendran, Thamaraiselvan Rengarajan, Natarajan Nandakumar, H. Divya, Ikuo Nishigaki

Research output: Contribution to journalArticlepeer-review

56 Scopus citations

Abstract

A variety of bioactive food components have been shown to modulate inflammatory responses and to attenuate carcinogenesis. Polyphenols isolated several years ago from various medicinal plants now seem to have a prominent role in the prevention and therapy of a variety of ailments. Mangiferin, a unique, important, and highly investigated polyphenol, has attracted much attention of late for its potential as a chemopreventive and chemotherapeutic agent against various types of cancer. Mangiferin has been shown to target multiple proinflammatory transcription factors, cell-cycle proteins, growth factors, kinases, cytokines, chemokines, adhesion molecules, and inflammatory enzymes. These targets can potentially mediate the chemopreventive and therapeutic effects of mangiferin by inhibiting the initiation, promotion, and metastasis of cancer. This review not only summarizes the diverse molecular targets of mangiferin, but also gives the results of various preclinical studies that have been performed in the last decade with this promising polyphenol.

Original languageEnglish
Pages (from-to)76-84
Number of pages9
JournalJournal of Receptor and Signal Transduction Research
Volume35
Issue number1
DOIs
StatePublished - 1 Feb 2015

Keywords

  • Cancer
  • Chemoprevention
  • Inflammation
  • Mangiferin
  • Polyphenol

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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