MANIPULATION OF METASTASIS AND TUMOUR GROWTH BY TRANSFECTION WITH HISTOCOMPATIBILITY CLASS I GENES

G. J. Hammerling; D. Klar; S. Katzav; S. Segal; M. Feldman; R. Wallich; A. Hämmerling

doi:10.1111/j.1744-313X.1986.tb01096.x

MANIPULATION OF METASTASIS AND TUMOUR GROWTH BY TRANSFECTION WITH HISTOCOMPATIBILITY CLASS I GENES

G. J. Hammerling, D. Klar, S. Katzav, S. Segal, M. Feldman, R. Wallich, A. Hämmerling

The Shraga Segal Department of Microbiology, Immunology and Genetics

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Approximately 50% of fibrosarcomas induced with methylcholanthrene A were found to be defective in H‐2 expression. In tumours which lack H‐2K antigens, H‐2 gene transfection was used to restore H‐2K expression. The de novo expression of H‐2K reduced tumorigenicity and abolished the formation of metastases in syngeneic mice. Expression of H‐2K seems to render the tumour cells immunogenic and leads to effective recognition of the tumour cells by the host immune system.

Original language	English
Pages (from-to)	153-157
Number of pages	5
Journal	International Journal of Immunogenetics
Volume	13
Issue number	2-3
DOIs	https://doi.org/10.1111/j.1744-313X.1986.tb01096.x
State	Published - 1 Jan 1986

ASJC Scopus subject areas

Immunology
Molecular Biology
Genetics
Genetics(clinical)

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title = "MANIPULATION OF METASTASIS AND TUMOUR GROWTH BY TRANSFECTION WITH HISTOCOMPATIBILITY CLASS I GENES",

abstract = "Approximately 50% of fibrosarcomas induced with methylcholanthrene A were found to be defective in H‐2 expression. In tumours which lack H‐2K antigens, H‐2 gene transfection was used to restore H‐2K expression. The de novo expression of H‐2K reduced tumorigenicity and abolished the formation of metastases in syngeneic mice. Expression of H‐2K seems to render the tumour cells immunogenic and leads to effective recognition of the tumour cells by the host immune system.",

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AU - Hammerling, G. J.

AU - Klar, D.

AU - Katzav, S.

AU - Segal, S.

AU - Feldman, M.

AU - Wallich, R.

AU - Hämmerling, A.

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AB - Approximately 50% of fibrosarcomas induced with methylcholanthrene A were found to be defective in H‐2 expression. In tumours which lack H‐2K antigens, H‐2 gene transfection was used to restore H‐2K expression. The de novo expression of H‐2K reduced tumorigenicity and abolished the formation of metastases in syngeneic mice. Expression of H‐2K seems to render the tumour cells immunogenic and leads to effective recognition of the tumour cells by the host immune system.

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ER -

MANIPULATION OF METASTASIS AND TUMOUR GROWTH BY TRANSFECTION WITH HISTOCOMPATIBILITY CLASS I GENES

Abstract

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