Mantle cell lymphoma in a tubular adenoma: unusual presentation with synchronous colonic carcinoma

Ignacio Sztarkier; Itai Levy; Shlomo Walfisch; Jorge Delgado; Daniel Benharroch

doi:10.1016/j.anndiagpath.2007.05.017

Mantle cell lymphoma in a tubular adenoma: unusual presentation with synchronous colonic carcinoma

Ignacio Sztarkier, Itai Levy, Shlomo Walfisch, Jorge Delgado, Daniel Benharroch

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

An 80-year-old man underwent sigmoidectomy for adenocarcinoma. Six months later, after a near-syncope incident, pancytopenia was detected in the absence of occult blood in the stools. A bone marrow biopsy showed malignant lymphoma, suggestive of mantle cell lymphoma (MCL). Colonoscopy at this time revealed 3 colonic tubular adenomas. Reassessment of the histology of the colonic polyps and appropriate immunohistochemical stains showed that the lamina propria of one of the tubular adenomas was infiltrated by MCL. Reexamination of the sections taken at the time of the original sigmoidectomy showed MCL in 2 of the regional lymph nodes removed at that time, but no evidence of lymphoma in the colon was found. To our knowledge, this is the fifth reported case of synchronous occurrence of intestinal MCL and colonic carcinoma and the first report of MCL presenting in a tubular adenoma of the colon.

Original language	English
Pages (from-to)	47-49
Number of pages	3
Journal	Annals of Diagnostic Pathology
Volume	13
Issue number	1
DOIs	https://doi.org/10.1016/j.anndiagpath.2007.05.017
State	Published - 1 Feb 2009
Externally published	Yes

Keywords

Colonic carcinoma
Mantle cell lymphoma
Tubular adenoma

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1016/j.anndiagpath.2007.05.017

Cite this

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title = "Mantle cell lymphoma in a tubular adenoma: unusual presentation with synchronous colonic carcinoma",

abstract = "An 80-year-old man underwent sigmoidectomy for adenocarcinoma. Six months later, after a near-syncope incident, pancytopenia was detected in the absence of occult blood in the stools. A bone marrow biopsy showed malignant lymphoma, suggestive of mantle cell lymphoma (MCL). Colonoscopy at this time revealed 3 colonic tubular adenomas. Reassessment of the histology of the colonic polyps and appropriate immunohistochemical stains showed that the lamina propria of one of the tubular adenomas was infiltrated by MCL. Reexamination of the sections taken at the time of the original sigmoidectomy showed MCL in 2 of the regional lymph nodes removed at that time, but no evidence of lymphoma in the colon was found. To our knowledge, this is the fifth reported case of synchronous occurrence of intestinal MCL and colonic carcinoma and the first report of MCL presenting in a tubular adenoma of the colon.",

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T2 - unusual presentation with synchronous colonic carcinoma

AU - Sztarkier, Ignacio

AU - Levy, Itai

AU - Walfisch, Shlomo

AU - Delgado, Jorge

AU - Benharroch, Daniel

PY - 2009/2/1

Y1 - 2009/2/1

N2 - An 80-year-old man underwent sigmoidectomy for adenocarcinoma. Six months later, after a near-syncope incident, pancytopenia was detected in the absence of occult blood in the stools. A bone marrow biopsy showed malignant lymphoma, suggestive of mantle cell lymphoma (MCL). Colonoscopy at this time revealed 3 colonic tubular adenomas. Reassessment of the histology of the colonic polyps and appropriate immunohistochemical stains showed that the lamina propria of one of the tubular adenomas was infiltrated by MCL. Reexamination of the sections taken at the time of the original sigmoidectomy showed MCL in 2 of the regional lymph nodes removed at that time, but no evidence of lymphoma in the colon was found. To our knowledge, this is the fifth reported case of synchronous occurrence of intestinal MCL and colonic carcinoma and the first report of MCL presenting in a tubular adenoma of the colon.

AB - An 80-year-old man underwent sigmoidectomy for adenocarcinoma. Six months later, after a near-syncope incident, pancytopenia was detected in the absence of occult blood in the stools. A bone marrow biopsy showed malignant lymphoma, suggestive of mantle cell lymphoma (MCL). Colonoscopy at this time revealed 3 colonic tubular adenomas. Reassessment of the histology of the colonic polyps and appropriate immunohistochemical stains showed that the lamina propria of one of the tubular adenomas was infiltrated by MCL. Reexamination of the sections taken at the time of the original sigmoidectomy showed MCL in 2 of the regional lymph nodes removed at that time, but no evidence of lymphoma in the colon was found. To our knowledge, this is the fifth reported case of synchronous occurrence of intestinal MCL and colonic carcinoma and the first report of MCL presenting in a tubular adenoma of the colon.

KW - Colonic carcinoma

KW - Mantle cell lymphoma

KW - Tubular adenoma

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Mantle cell lymphoma in a tubular adenoma: unusual presentation with synchronous colonic carcinoma

Abstract

Keywords

ASJC Scopus subject areas

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