TY - JOUR
T1 - Mantle cell lymphoma in a tubular adenoma
T2 - unusual presentation with synchronous colonic carcinoma
AU - Sztarkier, Ignacio
AU - Levy, Itai
AU - Walfisch, Shlomo
AU - Delgado, Jorge
AU - Benharroch, Daniel
PY - 2009/2/1
Y1 - 2009/2/1
N2 - An 80-year-old man underwent sigmoidectomy for adenocarcinoma. Six months later, after a near-syncope incident, pancytopenia was detected in the absence of occult blood in the stools. A bone marrow biopsy showed malignant lymphoma, suggestive of mantle cell lymphoma (MCL). Colonoscopy at this time revealed 3 colonic tubular adenomas. Reassessment of the histology of the colonic polyps and appropriate immunohistochemical stains showed that the lamina propria of one of the tubular adenomas was infiltrated by MCL. Reexamination of the sections taken at the time of the original sigmoidectomy showed MCL in 2 of the regional lymph nodes removed at that time, but no evidence of lymphoma in the colon was found. To our knowledge, this is the fifth reported case of synchronous occurrence of intestinal MCL and colonic carcinoma and the first report of MCL presenting in a tubular adenoma of the colon.
AB - An 80-year-old man underwent sigmoidectomy for adenocarcinoma. Six months later, after a near-syncope incident, pancytopenia was detected in the absence of occult blood in the stools. A bone marrow biopsy showed malignant lymphoma, suggestive of mantle cell lymphoma (MCL). Colonoscopy at this time revealed 3 colonic tubular adenomas. Reassessment of the histology of the colonic polyps and appropriate immunohistochemical stains showed that the lamina propria of one of the tubular adenomas was infiltrated by MCL. Reexamination of the sections taken at the time of the original sigmoidectomy showed MCL in 2 of the regional lymph nodes removed at that time, but no evidence of lymphoma in the colon was found. To our knowledge, this is the fifth reported case of synchronous occurrence of intestinal MCL and colonic carcinoma and the first report of MCL presenting in a tubular adenoma of the colon.
KW - Colonic carcinoma
KW - Mantle cell lymphoma
KW - Tubular adenoma
UR - http://www.scopus.com/inward/record.url?scp=57949104874&partnerID=8YFLogxK
U2 - 10.1016/j.anndiagpath.2007.05.017
DO - 10.1016/j.anndiagpath.2007.05.017
M3 - Article
C2 - 19118782
AN - SCOPUS:57949104874
SN - 1092-9134
VL - 13
SP - 47
EP - 49
JO - Annals of Diagnostic Pathology
JF - Annals of Diagnostic Pathology
IS - 1
ER -
