Manufacturing of nanochannels with controlled dimensions using protease nanolithography

Rodica E. Ionescu, Robert S. Marks, Levi A. Gheber

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


The feasibility of creating nanometer scale depressions in biological substrates using active enzymes delivered with scanning probe microscopes has been previously demonstrated by us and other groups. Here we present a comprehensive study revealing the dependence of channels dimensions on the parameters of the "writing" process and provide a simple way to precisely control their dimensions. Such nanochannels may be used in nanofluidic biochip applications.

Original languageEnglish
Pages (from-to)821-827
Number of pages7
JournalNano Letters
Issue number5
StatePublished - 1 May 2005

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry (all)
  • Materials Science (all)
  • Condensed Matter Physics
  • Mechanical Engineering


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