Manufacturing of nanochannels with controlled dimensions using protease nanolithography

Rodica E. Ionescu; Robert S. Marks; Levi A. Gheber

doi:10.1021/nl0500510

Manufacturing of nanochannels with controlled dimensions using protease nanolithography

Rodica E. Ionescu, Robert S. Marks, Levi A. Gheber

Department of Biotechnology Engineering

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

The feasibility of creating nanometer scale depressions in biological substrates using active enzymes delivered with scanning probe microscopes has been previously demonstrated by us and other groups. Here we present a comprehensive study revealing the dependence of channels dimensions on the parameters of the "writing" process and provide a simple way to precisely control their dimensions. Such nanochannels may be used in nanofluidic biochip applications.

Original language	English
Pages (from-to)	821-827
Number of pages	7
Journal	Nano Letters
Volume	5
Issue number	5
DOIs	https://doi.org/10.1021/nl0500510
State	Published - 1 May 2005

ASJC Scopus subject areas

Bioengineering
General Chemistry
General Materials Science
Condensed Matter Physics
Mechanical Engineering

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10.1021/nl0500510

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abstract = "The feasibility of creating nanometer scale depressions in biological substrates using active enzymes delivered with scanning probe microscopes has been previously demonstrated by us and other groups. Here we present a comprehensive study revealing the dependence of channels dimensions on the parameters of the {"}writing{"} process and provide a simple way to precisely control their dimensions. Such nanochannels may be used in nanofluidic biochip applications.",

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AU - Gheber, Levi A.

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AB - The feasibility of creating nanometer scale depressions in biological substrates using active enzymes delivered with scanning probe microscopes has been previously demonstrated by us and other groups. Here we present a comprehensive study revealing the dependence of channels dimensions on the parameters of the "writing" process and provide a simple way to precisely control their dimensions. Such nanochannels may be used in nanofluidic biochip applications.

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Manufacturing of nanochannels with controlled dimensions using protease nanolithography

Abstract

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