@inproceedings{99b1a9cdab464f41a83454b63a594a06,
title = "Mapping tissue chromophore changes in cerebral ischemia: A pilot study",
abstract = "We describe the projection of spatially modulated light for quantitatively mapping changes in oxyhemoglobin, deoxyhemoglobin, and oxygen saturation in two pilot studies in the rat barrel cortex during both permanent and temporary cerebral ischemia. The approach is based on the projection of spatial modulation of white light onto the brain. The reflected light is captured on a CCD camera, which is then processed to obtain the concentration and distribution of chromophores over a wide field. Preliminary results confirm a measurable and quantifiable increase in tissue molecular concentration of deoxy-hemoglobin and decrease in hemoglobin oxygen concentration in both experimental settings. Our preliminary data from our pilot studies demonstrate that spatial modulation of light can provide quantitative chromophore mapping of the brain and has a potential role in monitoring the course and severity of cerebral ischemia in cerebrovascular disease patients.",
keywords = "Brain injury, Cerebral hemodynamics, Optical properties, Spatially modulate light, Stroke",
author = "David Abookasis and Mathews, {Marlon S.} and Christopher Lay and Cuccia, {David J.} and Frostig, {Ron D.} and Linskey, {Mark E.} and Tromberg, {Bruce J.}",
year = "2007",
month = aug,
day = "31",
doi = "10.1117/12.718430",
language = "English",
isbn = "0819465372",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
booktitle = "Photonic Therapeutics and Diagnostics III",
note = "Photonic Therapeutics and Diagnostics III ; Conference date: 20-01-2007 Through 21-01-2007",
}
