Mapping tissue chromophore changes in cerebral ischemia: A pilot study

David Abookasis; Marlon S. Mathews; Christopher Lay; David J. Cuccia; Ron D. Frostig; Mark E. Linskey; Bruce J. Tromberg

doi:10.1117/12.718430

Mapping tissue chromophore changes in cerebral ischemia: A pilot study

David Abookasis
, Marlon S. Mathews
, Christopher Lay
, David J. Cuccia
, Ron D. Frostig
, Mark E. Linskey
, Bruce J. Tromberg

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

We describe the projection of spatially modulated light for quantitatively mapping changes in oxyhemoglobin, deoxyhemoglobin, and oxygen saturation in two pilot studies in the rat barrel cortex during both permanent and temporary cerebral ischemia. The approach is based on the projection of spatial modulation of white light onto the brain. The reflected light is captured on a CCD camera, which is then processed to obtain the concentration and distribution of chromophores over a wide field. Preliminary results confirm a measurable and quantifiable increase in tissue molecular concentration of deoxy-hemoglobin and decrease in hemoglobin oxygen concentration in both experimental settings. Our preliminary data from our pilot studies demonstrate that spatial modulation of light can provide quantitative chromophore mapping of the brain and has a potential role in monitoring the course and severity of cerebral ischemia in cerebrovascular disease patients.

Original language	English
Title of host publication	Photonic Therapeutics and Diagnostics III
DOIs	https://doi.org/10.1117/12.718430
State	Published - 31 Aug 2007
Externally published	Yes
Event	Photonic Therapeutics and Diagnostics III - San Jose, CA, United States Duration: 20 Jan 2007 → 21 Jan 2007

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	6424
ISSN (Print)	1605-7422

Conference

Conference	Photonic Therapeutics and Diagnostics III
Country/Territory	United States
City	San Jose, CA
Period	20/01/07 → 21/01/07

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Brain injury
Cerebral hemodynamics
Optical properties
Spatially modulate light
Stroke

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics
Biomaterials
Radiology Nuclear Medicine and imaging

Access to Document

10.1117/12.718430

Cite this

@inproceedings{99b1a9cdab464f41a83454b63a594a06,

title = "Mapping tissue chromophore changes in cerebral ischemia: A pilot study",

abstract = "We describe the projection of spatially modulated light for quantitatively mapping changes in oxyhemoglobin, deoxyhemoglobin, and oxygen saturation in two pilot studies in the rat barrel cortex during both permanent and temporary cerebral ischemia. The approach is based on the projection of spatial modulation of white light onto the brain. The reflected light is captured on a CCD camera, which is then processed to obtain the concentration and distribution of chromophores over a wide field. Preliminary results confirm a measurable and quantifiable increase in tissue molecular concentration of deoxy-hemoglobin and decrease in hemoglobin oxygen concentration in both experimental settings. Our preliminary data from our pilot studies demonstrate that spatial modulation of light can provide quantitative chromophore mapping of the brain and has a potential role in monitoring the course and severity of cerebral ischemia in cerebrovascular disease patients.",

keywords = "Brain injury, Cerebral hemodynamics, Optical properties, Spatially modulate light, Stroke",

author = "David Abookasis and Mathews, \{Marlon S.\} and Christopher Lay and Cuccia, \{David J.\} and Frostig, \{Ron D.\} and Linskey, \{Mark E.\} and Tromberg, \{Bruce J.\}",

year = "2007",

month = aug,

day = "31",

doi = "10.1117/12.718430",

language = "English",

isbn = "0819465372",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

booktitle = "Photonic Therapeutics and Diagnostics III",

note = "Photonic Therapeutics and Diagnostics III ; Conference date: 20-01-2007 Through 21-01-2007",

}

Abookasis, D, Mathews, MS, Lay, C, Cuccia, DJ, Frostig, RD, Linskey, ME & Tromberg, BJ 2007, Mapping tissue chromophore changes in cerebral ischemia: A pilot study. in Photonic Therapeutics and Diagnostics III., 64242J, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 6424, Photonic Therapeutics and Diagnostics III, San Jose, CA, United States, 20/01/07. https://doi.org/10.1117/12.718430

Mapping tissue chromophore changes in cerebral ischemia: A pilot study. / Abookasis, David; Mathews, Marlon S.; Lay, Christopher et al.
Photonic Therapeutics and Diagnostics III. 2007. 64242J (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6424).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Mapping tissue chromophore changes in cerebral ischemia

T2 - Photonic Therapeutics and Diagnostics III

AU - Abookasis, David

AU - Mathews, Marlon S.

AU - Lay, Christopher

AU - Cuccia, David J.

AU - Frostig, Ron D.

AU - Linskey, Mark E.

AU - Tromberg, Bruce J.

PY - 2007/8/31

Y1 - 2007/8/31

N2 - We describe the projection of spatially modulated light for quantitatively mapping changes in oxyhemoglobin, deoxyhemoglobin, and oxygen saturation in two pilot studies in the rat barrel cortex during both permanent and temporary cerebral ischemia. The approach is based on the projection of spatial modulation of white light onto the brain. The reflected light is captured on a CCD camera, which is then processed to obtain the concentration and distribution of chromophores over a wide field. Preliminary results confirm a measurable and quantifiable increase in tissue molecular concentration of deoxy-hemoglobin and decrease in hemoglobin oxygen concentration in both experimental settings. Our preliminary data from our pilot studies demonstrate that spatial modulation of light can provide quantitative chromophore mapping of the brain and has a potential role in monitoring the course and severity of cerebral ischemia in cerebrovascular disease patients.

AB - We describe the projection of spatially modulated light for quantitatively mapping changes in oxyhemoglobin, deoxyhemoglobin, and oxygen saturation in two pilot studies in the rat barrel cortex during both permanent and temporary cerebral ischemia. The approach is based on the projection of spatial modulation of white light onto the brain. The reflected light is captured on a CCD camera, which is then processed to obtain the concentration and distribution of chromophores over a wide field. Preliminary results confirm a measurable and quantifiable increase in tissue molecular concentration of deoxy-hemoglobin and decrease in hemoglobin oxygen concentration in both experimental settings. Our preliminary data from our pilot studies demonstrate that spatial modulation of light can provide quantitative chromophore mapping of the brain and has a potential role in monitoring the course and severity of cerebral ischemia in cerebrovascular disease patients.

KW - Brain injury

KW - Cerebral hemodynamics

KW - Optical properties

KW - Spatially modulate light

KW - Stroke

UR - https://www.scopus.com/pages/publications/34548202756

U2 - 10.1117/12.718430

DO - 10.1117/12.718430

M3 - Conference contribution

AN - SCOPUS:34548202756

SN - 0819465372

SN - 9780819465375

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Photonic Therapeutics and Diagnostics III

Y2 - 20 January 2007 through 21 January 2007

ER -

Mapping tissue chromophore changes in cerebral ischemia: A pilot study

Abstract

Publication series

Conference

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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