Mass antibiotic treatment to stop an outbreak of meningococcal disease: A molecular analysis

Liors Hlomit Katz; A. Zelazny; S. Scharf; A. Hourvitz; N. Asor; Y. Arbeli; S. Yust-Katz; G. Smollan-Fredman; M. Gdalevich

doi:10.1111/j.1469-0691.2007.01767.x

Mass antibiotic treatment to stop an outbreak of meningococcal disease: A molecular analysis

Liors Hlomit Katz, A. Zelazny, S. Scharf, A. Hourvitz, N. Asor, Y. Arbeli, S. Yust-Katz, G. Smollan-Fredman, M. Gdalevich

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The occurrence of three cases of meningococcal disease among children in a small community, two of whom attended the same day-care centre, prompted a programme of mass antibiotic prophylaxis. Nasopharyngeal and throat swabs were obtained on three occasions from all children registered at the day-care centre. Serogroup B Neisseria meningitidis was isolated from 13 of 61 children before prophylaxis, from three children after 2 weeks, and from 19 children after 3 months. Repetitive extragenic palindromic PCR analysis identified several meningococcal strains before treatment, one of which became predominant after 3 months. Mass antibiotic prophylaxis initially suppressed meningococcal carriage, but the carriage rate subsequently rebounded.

Original language	English
Pages (from-to)	943-946
Number of pages	4
Journal	Clinical Microbiology and Infection
Volume	13
Issue number	9
DOIs	https://doi.org/10.1111/j.1469-0691.2007.01767.x
State	Published - 1 Jan 2007
Externally published	Yes

Keywords

Carriage
Children
Meningococci
Neisseria meningitidis
Prophylaxis
REP-PCR

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

Access to Document

10.1111/j.1469-0691.2007.01767.x

Cite this

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title = "Mass antibiotic treatment to stop an outbreak of meningococcal disease: A molecular analysis",

abstract = "The occurrence of three cases of meningococcal disease among children in a small community, two of whom attended the same day-care centre, prompted a programme of mass antibiotic prophylaxis. Nasopharyngeal and throat swabs were obtained on three occasions from all children registered at the day-care centre. Serogroup B Neisseria meningitidis was isolated from 13 of 61 children before prophylaxis, from three children after 2 weeks, and from 19 children after 3 months. Repetitive extragenic palindromic PCR analysis identified several meningococcal strains before treatment, one of which became predominant after 3 months. Mass antibiotic prophylaxis initially suppressed meningococcal carriage, but the carriage rate subsequently rebounded.",

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AU - Katz, Liors Hlomit

AU - Zelazny, A.

AU - Scharf, S.

AU - Hourvitz, A.

AU - Asor, N.

AU - Arbeli, Y.

AU - Yust-Katz, S.

AU - Smollan-Fredman, G.

AU - Gdalevich, M.

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AB - The occurrence of three cases of meningococcal disease among children in a small community, two of whom attended the same day-care centre, prompted a programme of mass antibiotic prophylaxis. Nasopharyngeal and throat swabs were obtained on three occasions from all children registered at the day-care centre. Serogroup B Neisseria meningitidis was isolated from 13 of 61 children before prophylaxis, from three children after 2 weeks, and from 19 children after 3 months. Repetitive extragenic palindromic PCR analysis identified several meningococcal strains before treatment, one of which became predominant after 3 months. Mass antibiotic prophylaxis initially suppressed meningococcal carriage, but the carriage rate subsequently rebounded.

KW - Carriage

KW - Children

KW - Meningococci

KW - Neisseria meningitidis

KW - Prophylaxis

KW - REP-PCR

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Mass antibiotic treatment to stop an outbreak of meningococcal disease: A molecular analysis

Abstract

Keywords

ASJC Scopus subject areas

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