Massive proteinuria as a main manifestation of primary antiphospholipid syndrome

Y. Levy; J. George; L. Ziporen; J. Cledes; H. Amital; Y. Bar-Dayan; A. Afek; P. Youinou; Y. Shoenfeld

doi:10.1159/000027995

Massive proteinuria as a main manifestation of primary antiphospholipid syndrome

Y. Levy
, J. George
, L. Ziporen
, J. Cledes
, H. Amital
, Y. Bar-Dayan
, A. Afek
, P. Youinou
, Y. Shoenfeld

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Renal involvement in antiphospholipid syndrome (APS) is increasingly reported. So far, massive proteinuria as the principal feature of primary APS (PAPS) has not been well documented. We describe 3 patients with PAPS and massiv proteinuria. Renal biopsy was performed in all 3, and features consistent with membranous and focal segmental glomerulopathy were disclosed. These histological lesions were not yet reported in PAPS. We conclude that the spectrum of renal lesions in PAPS is diverse and that it should be considered in the differential diagnosis of patients with massive proteinuria.

Original language	English
Pages (from-to)	49-52
Number of pages	4
Journal	Pathobiology
Volume	66
Issue number	1
DOIs	https://doi.org/10.1159/000027995
State	Published - 8 Apr 1998
Externally published	Yes

Keywords

Antiphospholipid syndrome
Focal segmental glomerulosclerosis
Membranous glomerulopathy
Proteinuria
Renal involvement

ASJC Scopus subject areas

Pathology and Forensic Medicine
Molecular Biology
Cell Biology

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10.1159/000027995

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title = "Massive proteinuria as a main manifestation of primary antiphospholipid syndrome",

abstract = "Renal involvement in antiphospholipid syndrome (APS) is increasingly reported. So far, massive proteinuria as the principal feature of primary APS (PAPS) has not been well documented. We describe 3 patients with PAPS and massiv proteinuria. Renal biopsy was performed in all 3, and features consistent with membranous and focal segmental glomerulopathy were disclosed. These histological lesions were not yet reported in PAPS. We conclude that the spectrum of renal lesions in PAPS is diverse and that it should be considered in the differential diagnosis of patients with massive proteinuria.",

keywords = "Antiphospholipid syndrome, Focal segmental glomerulosclerosis, Membranous glomerulopathy, Proteinuria, Renal involvement",

author = "Y. Levy and J. George and L. Ziporen and J. Cledes and H. Amital and Y. Bar-Dayan and A. Afek and P. Youinou and Y. Shoenfeld",

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AU - Levy, Y.

AU - George, J.

AU - Ziporen, L.

AU - Cledes, J.

AU - Amital, H.

AU - Bar-Dayan, Y.

AU - Afek, A.

AU - Youinou, P.

AU - Shoenfeld, Y.

PY - 1998/4/8

Y1 - 1998/4/8

N2 - Renal involvement in antiphospholipid syndrome (APS) is increasingly reported. So far, massive proteinuria as the principal feature of primary APS (PAPS) has not been well documented. We describe 3 patients with PAPS and massiv proteinuria. Renal biopsy was performed in all 3, and features consistent with membranous and focal segmental glomerulopathy were disclosed. These histological lesions were not yet reported in PAPS. We conclude that the spectrum of renal lesions in PAPS is diverse and that it should be considered in the differential diagnosis of patients with massive proteinuria.

AB - Renal involvement in antiphospholipid syndrome (APS) is increasingly reported. So far, massive proteinuria as the principal feature of primary APS (PAPS) has not been well documented. We describe 3 patients with PAPS and massiv proteinuria. Renal biopsy was performed in all 3, and features consistent with membranous and focal segmental glomerulopathy were disclosed. These histological lesions were not yet reported in PAPS. We conclude that the spectrum of renal lesions in PAPS is diverse and that it should be considered in the differential diagnosis of patients with massive proteinuria.

KW - Antiphospholipid syndrome

KW - Focal segmental glomerulosclerosis

KW - Membranous glomerulopathy

KW - Proteinuria

KW - Renal involvement

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DO - 10.1159/000027995

M3 - Article

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AN - SCOPUS:0031911809

SN - 1015-2008

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EP - 52

JO - Pathobiology

JF - Pathobiology

IS - 1

ER -

Massive proteinuria as a main manifestation of primary antiphospholipid syndrome

Abstract

Keywords

ASJC Scopus subject areas

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