Massive splenomegaly responsive to proguanil and with features of hairy cell leukaemia

Tikvah Yermiyahu, Maximo Maislos, Alla Shneider, David Ben Meir, Mark N. Lowenthal

    Research output: Contribution to journalArticlepeer-review

    4 Scopus citations

    Abstract

    A recent Ethiopian immigrant to Israel presented with pneumococcal sepsis, massive splenomegaly and lymphadenopathy. Investigations revealed many features of both hairy cell leukaemia (HCL) and hyperreactive malarious splenomegaly (HMS). Proguanil therapy for HMS was followed by rapid, marked decrease in spleen size, disappearance of the tartrate-resistant acid phosphatase-positive cells characteristic of HCL, and increasing eosinophilia, but unchanged lymphadenopathy.

    Original languageEnglish
    Pages (from-to)194-196
    Number of pages3
    JournalTransactions of the Royal Society of Tropical Medicine and Hygiene
    Volume89
    Issue number2
    DOIs
    StatePublished - 1 Jan 1995

    Keywords

    • Hairy cell leukaemia
    • Proguanil
    • Splenomegaly

    ASJC Scopus subject areas

    • Parasitology
    • Public Health, Environmental and Occupational Health
    • Infectious Diseases

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