Maternal and Neonatal Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant Neutralization after Antenatal Messenger RNA Vaccination

Amihai Rottenstreich; Olesya Vorontsov; Or Alfi; Gila Zarbiv; Esther Oiknine-Djian; Roy Zigron; Geffen Kleinstern; Michal Mandelboim; Shay Porat; Dana G. Wolf

doi:10.1093/cid/ciac395

Maternal and Neonatal Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant Neutralization after Antenatal Messenger RNA Vaccination

Amihai Rottenstreich, Olesya Vorontsov, Or Alfi, Gila Zarbiv, Esther Oiknine-Djian, Roy Zigron, Geffen Kleinstern, Michal Mandelboim, Shay Porat, Dana G. Wolf

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

We evaluated the neutralization efficiency against SARS-CoV-2 Omicron variant in maternal and cord blood sera after antenatal BNT162b2 vaccination. Neutralizing antibodies against Omicron were lacking at the time of delivery after 2-dose vaccination. A third booster dose was essential in building neutralizing antibody capacity against Omicron among mothers and neonates.

Original language	English
Pages (from-to)	2023-2026
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	75
Issue number	11
DOIs	https://doi.org/10.1093/cid/ciac395
State	Published - 1 Dec 2022
Externally published	Yes

Keywords

COVID-19
Omicron
SARS-CoV-2
pregnancy
vaccination

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/cid/ciac395

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Rottenstreich, A., Vorontsov, O., Alfi, O., Zarbiv, G., Oiknine-Djian, E., Zigron, R., Kleinstern, G., Mandelboim, M., Porat, S., & Wolf, D. G. (2022). Maternal and Neonatal Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant Neutralization after Antenatal Messenger RNA Vaccination. Clinical Infectious Diseases, 75(11), 2023-2026. https://doi.org/10.1093/cid/ciac395

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abstract = "We evaluated the neutralization efficiency against SARS-CoV-2 Omicron variant in maternal and cord blood sera after antenatal BNT162b2 vaccination. Neutralizing antibodies against Omicron were lacking at the time of delivery after 2-dose vaccination. A third booster dose was essential in building neutralizing antibody capacity against Omicron among mothers and neonates.",

keywords = "COVID-19, Omicron, SARS-CoV-2, pregnancy, vaccination",

author = "Amihai Rottenstreich and Olesya Vorontsov and Or Alfi and Gila Zarbiv and Esther Oiknine-Djian and Roy Zigron and Geffen Kleinstern and Michal Mandelboim and Shay Porat and Wolf, \{Dana G.\}",

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doi = "10.1093/cid/ciac395",

language = "English",

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Rottenstreich, A, Vorontsov, O, Alfi, O, Zarbiv, G, Oiknine-Djian, E, Zigron, R, Kleinstern, G, Mandelboim, M, Porat, S & Wolf, DG 2022, 'Maternal and Neonatal Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant Neutralization after Antenatal Messenger RNA Vaccination', Clinical Infectious Diseases, vol. 75, no. 11, pp. 2023-2026. https://doi.org/10.1093/cid/ciac395

TY - JOUR

T1 - Maternal and Neonatal Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant Neutralization after Antenatal Messenger RNA Vaccination

AU - Rottenstreich, Amihai

AU - Vorontsov, Olesya

AU - Alfi, Or

AU - Zarbiv, Gila

AU - Oiknine-Djian, Esther

AU - Zigron, Roy

AU - Kleinstern, Geffen

AU - Mandelboim, Michal

AU - Porat, Shay

AU - Wolf, Dana G.

PY - 2022/12/1

Y1 - 2022/12/1

N2 - We evaluated the neutralization efficiency against SARS-CoV-2 Omicron variant in maternal and cord blood sera after antenatal BNT162b2 vaccination. Neutralizing antibodies against Omicron were lacking at the time of delivery after 2-dose vaccination. A third booster dose was essential in building neutralizing antibody capacity against Omicron among mothers and neonates.

AB - We evaluated the neutralization efficiency against SARS-CoV-2 Omicron variant in maternal and cord blood sera after antenatal BNT162b2 vaccination. Neutralizing antibodies against Omicron were lacking at the time of delivery after 2-dose vaccination. A third booster dose was essential in building neutralizing antibody capacity against Omicron among mothers and neonates.

KW - COVID-19

KW - Omicron

KW - SARS-CoV-2

KW - pregnancy

KW - vaccination

UR - https://www.scopus.com/pages/publications/85143180545

U2 - 10.1093/cid/ciac395

DO - 10.1093/cid/ciac395

M3 - Article

C2 - 35607735

AN - SCOPUS:85143180545

SN - 1058-4838

VL - 75

SP - 2023

EP - 2026

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 11

ER -

Maternal and Neonatal Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant Neutralization after Antenatal Messenger RNA Vaccination

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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