Maternal drug allergy and long- term respiratory morbidity of the offspring

Ofir Almasi, Tamar Wainstock, Eyal Sheiner, Gali Pariente

Research output: Contribution to journalMeeting Abstract

Abstract

Objective
Drug allergy is considered a common occurrence among pregnant women. It has been associated with adverse short-term perinatal outcomes such as caesarian section, preterm delivery and diabetes. The aim of the present study was to determine whether being born to a mother with drug allergy increases the risk for long-term dermatological morbidity of the offspring

Study Design
A population-based cohort study, comparing long term dermatological morbidity of offspring to mothers with and without drug allergy was conducted. All singleton deliveries between 1991-2014 in tertiary medical center were included. Multiple pregnancies, offspring with congenital malformations and cases of perinatal death were excluded from the analysis. Dermatological morbidity was assessed up to the age of 18 years according to a predefined set of ICD-9 codes associated with hospitalization of the offspring. A Kaplan-Meier survival curve was used to compare cumulative incidence of long-term dermatological morbidity, and a Cox proportional hazards model was constructed to control of confounders

Results
During the study period, 242,342 deliveries met the inclusion criteria, of them 4% (n= 9714) were of mothers with drug allergy. Offspring born to mothers with drug allergy had higher rates of dermatological morbidity and specifically higher rates of allergic and immune reactions (Table). Likewise, the cumulative incidence of long-term dermatological morbidity was higher as compared with those without drug allergy (Kaplan-Meier log-rank, P value=0.021, figure). Using a Cox proportional hazards model, controlling for confounders such as maternal age, hypertensive disorders, birth-weight, caesarian section and maternal diabetes mellitus, being born to a mother with drug allergy was found to be an independent risk factor for long term dermatological morbidity of the offspring (adjusted HR 1.2, 95% CI 1.03-1.33, P value= 0.016).

Conclusion
Being born to a mother with drug allergy is independently associated with higher risk for long term dermatological morbidity of the offspring
Original languageEnglish
Pages (from-to)S593-S594
JournalAmerican Journal of Obstetrics and Gynecology
Volume222
Issue number1
DOIs
StatePublished - Jan 2020

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