Maternal history of recurrent pregnancy loss is associated with increased risk for long-term pediatric gastrointestinal morbidity in the offspring

Yael Lichtman, Eyal Sheiner, Tamar Wainstock, Idit Segal, Daniella Landau, Asnat Walfisch

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Problem: Recurrent pregnancy loss (RPL) potentially involves an abnormal maternal inflammatory response. We investigated whether children of mothers with a history of RPL are at an increased risk for childhood gastrointestinal (GI) morbidity, with a specific focus on inflammatory bowel diseases (IBD). Method of study: A population-based cohort analysis comparing the risk for long-term GI morbidity in children born to mothers with and without a history of RPL. Gastrointestinal (GI) morbidity included hospitalizations involving a pre-defined set of ICD-9 codes. Results: During the study period, 242 186 newborns met the inclusion criteria; 5% of which were offspring to mothers with a history of RPL. Gastrointestinal morbidity was significantly more common in the RPL group (6.6% vs 5.3%). Specifically, offspring to mothers with a history of RPL had significantly higher rates of IBD (2.1% vs 1.7%). Conclusion: Maternal history of RPL is associated with an increased risk for pediatric GI morbidity in the offspring.

Original languageEnglish
Article numbere12799
JournalAmerican Journal of Reproductive Immunology
Volume79
Issue number2
DOIs
StatePublished - 1 Feb 2018

Keywords

  • inflammatory bowel disease
  • miscarriage
  • pediatric morbidity
  • pregnancy
  • recurrent abortions

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Reproductive Medicine
  • Obstetrics and Gynecology

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