Maternal known drug allergy and long-term dermatological morbidity of the offspring

Ariel Noy, Tamar Wainstock, Eyal Sheiner, Tom Leibson, Amir Horev, Gali Pariente

Research output: Contribution to journalReview articlepeer-review

Abstract

Drug allergy is associated with adverse short-term perinatal outcomes such as caesarian delivery and preterm delivery. The aim of the present study was to determine whether being born to a mother with known drug allergy increases the risk for long-term dermatological morbidity of the offspring. A population-based cohort study, comparing long-term dermatological morbidity of offspring to mothers with and without known drug allergy, was conducted. Dermatological morbidity was assessed up to the age of 18 years according to a predefined set of ICD-9 codes associated with hospitalization of the offspring. A Kaplan-Meier survival curve was used to compare cumulative incidence of long-term dermatological morbidity, and a Cox proportional hazards model was constructed to control of confounders. During the study period, 243,682 deliveries met the inclusion criteria, of them 4% (n = 9756) were of mothers with known drug allergy. Offspring born to mothers with known drug allergy had higher rates of long-term dermatological morbidity Likewise, the cumulative incidence of long-term dermatological morbidity was higher as compared with those without known drug allergy (Kaplan-Meier log-rank P =.021). Using a Cox proportional hazards model, controlling for confounders, being born to a mother with known drug allergy was found to be an independent risk factor for long-term dermatological morbidity of the offspring (adjusted HR 1.2, 95% CI 1.03-1.33, P =.016). Being born to a mother with known drug allergy is independently associated with higher risk for long-term dermatological morbidity of the offspring.

Original languageEnglish
Article numbere13356
JournalAmerican Journal of Reproductive Immunology
Volume85
Issue number1
DOIs
StatePublished - 1 Jan 2021

Keywords

  • dermatological morbidities
  • drug allergy
  • offspring
  • pregnancy outcomes

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