Maternal plasma visfatin in preterm labor

Shali Mazaki-Tovi, Roberto Romero, Edi Vaisbuch, Offer Erez, Tinnakorn Chaiworapongsa, Pooja Mittal, Sun Kwon Kim, Percy Pacora, Francesca Gotsch, Zhong Dong, Sonia S. Hassan, Juan Pedro Kusanovic

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Objective. Visfatin, a novel adipokine with diabetogenic and immunoregulatory properties, has been implicated in the pathophysiology of insulin resistance, as well as in various acute and chronic inflammatory disorders. We have previously reported that amniotic fluid concentrations of visfatin are higher in patients with preterm labor PTL and intra-amniotic infection than in patients with PTL without infection. The aim of this study was to determine whether spontaneous PTL with intact membranes and intra-amniotic infectioninflammation IAI is associated with changes in maternal plasma circulating visfatin concentrations. Study design. This cross-sectional study included patients in the following groups: 1 normal pregnant women n 123; 2 patients with an episode of PTL and intact membranes without IAI who delivered at term n 57; 3 PTL without IAI who delivered preterm n 47; and 4 PTL with IAI who delivered preterm n 57. Plasma visfatin concentrations were determined by ELISA. Non-parametric statistics were used for analysis. Results.1 PTL with IAI leading to preterm delivery was associated with a higher median maternal plasma concentration of visfatin than normal pregnancy; 2 among patients with PTL, those with IAI had the highest median maternal concentration of visfatin; 3 the changes in maternal plasma visfatin remained significant after adjusting for maternal age, body mass index, gestational age at sampling, and birth weight. Conclusion.1 PTL with IAI is characterized by high maternal circulating visfatin concentrations; 2 these findings suggest that visfatin plays a role in the regulation of the metabolic adaptations to insults resulting in PTL in the context of IAI.

Original languageEnglish
Pages (from-to)693-704
Number of pages12
JournalJournal of Maternal-Fetal and Neonatal Medicine
Issue number8
StatePublished - 9 Nov 2009
Externally publishedYes


  • Adipokines
  • Chorioamnionitis
  • Energy expenditure
  • Energy requirements
  • Inflammation
  • Intra-amniotic infection
  • Metabolism
  • Pregnancy
  • Preterm birth
  • Preterm delivery
  • Preterm labor
  • Visfatin

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology


Dive into the research topics of 'Maternal plasma visfatin in preterm labor'. Together they form a unique fingerprint.

Cite this