Abstract
Objective
Preeclampsia was shown to be associated with pregnancy and delivery complications, as well as maternal and infant morbidity and mortality in the short-term. We aimed to study the long-term effect of preeclampsia during pregnancy on the risk for subsequent childhood gastrointestinal morbidity of the offspring.
Study Design
We performed a population based cohort analysis comparing total and different subtypes of gastrointestinal related pediatric hospitalizations among offspring of preeclamptic and eclamptic- mothers versus offspring of mothers without preeclampsia. The analysis included all singletons born between the years 1999-2014 at a single tertiary regional medical center. Gastrointestinal related morbidities included hospitalizations involving a pre-defined set of ICD-9 codes, as recorded in hospital computerized files. Infants with congenital malformations, multiple gestations, and all perinatal deaths were excluded from the analysis. A Kaplan-Meier survival curve was used to compare the cumulative morbidity, and a Cox proportional hazards model was constructed to adjust for confounders.
Results
The study population included 239,687 newborns who met inclusion criteria; among them 2222 (0.93%) were born to mothers with severe preeclampsia or eclampsia, and 7279 (3.03%) were born to mothers with mild preeclampsia. Offspring of mothers with severe preeclampsia and eclampsia had significantly higher rates of gastrointestinal- related hospitalizations in comparison to offspring of mothers with mild preeclampsia and offspring of non- preeclamptic mothers (7.7% vs. 5.5% vs. 5.3%, respectively; p<0.001 using the chi-square test for trends; Kaplan-Meier survival curve presented in graph). The association between exposure to severe preeclampsia and eclampsia in utero and long-term gastrointestinal morbidity of the offspring remained significant and independent while adjusting for gestational age and maternal age, using a Cox proportional hazards model (Adjusted HR=1.2, 95% CI 1.0-1.4; p =0.019).
Conclusion
In our population severe preeclampsia and eclampsia are independent risk factors for pediatric gastrointestinal morbidity of the offspring.
Preeclampsia was shown to be associated with pregnancy and delivery complications, as well as maternal and infant morbidity and mortality in the short-term. We aimed to study the long-term effect of preeclampsia during pregnancy on the risk for subsequent childhood gastrointestinal morbidity of the offspring.
Study Design
We performed a population based cohort analysis comparing total and different subtypes of gastrointestinal related pediatric hospitalizations among offspring of preeclamptic and eclamptic- mothers versus offspring of mothers without preeclampsia. The analysis included all singletons born between the years 1999-2014 at a single tertiary regional medical center. Gastrointestinal related morbidities included hospitalizations involving a pre-defined set of ICD-9 codes, as recorded in hospital computerized files. Infants with congenital malformations, multiple gestations, and all perinatal deaths were excluded from the analysis. A Kaplan-Meier survival curve was used to compare the cumulative morbidity, and a Cox proportional hazards model was constructed to adjust for confounders.
Results
The study population included 239,687 newborns who met inclusion criteria; among them 2222 (0.93%) were born to mothers with severe preeclampsia or eclampsia, and 7279 (3.03%) were born to mothers with mild preeclampsia. Offspring of mothers with severe preeclampsia and eclampsia had significantly higher rates of gastrointestinal- related hospitalizations in comparison to offspring of mothers with mild preeclampsia and offspring of non- preeclamptic mothers (7.7% vs. 5.5% vs. 5.3%, respectively; p<0.001 using the chi-square test for trends; Kaplan-Meier survival curve presented in graph). The association between exposure to severe preeclampsia and eclampsia in utero and long-term gastrointestinal morbidity of the offspring remained significant and independent while adjusting for gestational age and maternal age, using a Cox proportional hazards model (Adjusted HR=1.2, 95% CI 1.0-1.4; p =0.019).
Conclusion
In our population severe preeclampsia and eclampsia are independent risk factors for pediatric gastrointestinal morbidity of the offspring.
| Original language | English GB |
|---|---|
| Pages (from-to) | S475-S475 |
| Journal | American Journal of Obstetrics and Gynecology |
| Volume | 220 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2019 |