Maternal preeclampsia and the risk of gastrointestinal disease of the offspring: A population-based cohort study

Noa S. Leybovitz-Haleluya, Tamar Wainstock, Eyal Sheiner

Research output: Contribution to journalMeeting Abstract


Preeclampsia was shown to be associated with pregnancy and delivery complications, as well as maternal and infant morbidity and mortality in the short-term. We aimed to study the long-term effect of preeclampsia during pregnancy on the risk for subsequent childhood gastrointestinal morbidity of the offspring.

Study Design
We performed a population based cohort analysis comparing total and different subtypes of gastrointestinal related pediatric hospitalizations among offspring of preeclamptic and eclamptic- mothers versus offspring of mothers without preeclampsia. The analysis included all singletons born between the years 1999-2014 at a single tertiary regional medical center. Gastrointestinal related morbidities included hospitalizations involving a pre-defined set of ICD-9 codes, as recorded in hospital computerized files. Infants with congenital malformations, multiple gestations, and all perinatal deaths were excluded from the analysis. A Kaplan-Meier survival curve was used to compare the cumulative morbidity, and a Cox proportional hazards model was constructed to adjust for confounders.

The study population included 239,687 newborns who met inclusion criteria; among them 2222 (0.93%) were born to mothers with severe preeclampsia or eclampsia, and 7279 (3.03%) were born to mothers with mild preeclampsia. Offspring of mothers with severe preeclampsia and eclampsia had significantly higher rates of gastrointestinal- related hospitalizations in comparison to offspring of mothers with mild preeclampsia and offspring of non- preeclamptic mothers (7.7% vs. 5.5% vs. 5.3%, respectively; p<0.001 using the chi-square test for trends; Kaplan-Meier survival curve presented in graph). The association between exposure to severe preeclampsia and eclampsia in utero and long-term gastrointestinal morbidity of the offspring remained significant and independent while adjusting for gestational age and maternal age, using a Cox proportional hazards model (Adjusted HR=1.2, 95% CI 1.0-1.4; p =0.019).

In our population severe preeclampsia and eclampsia are independent risk factors for pediatric gastrointestinal morbidity of the offspring.
Original languageEnglish GB
Pages (from-to)S475-S475
JournalAmerican Journal of Obstetrics and Gynecology
Issue number1
StatePublished - Jan 2019


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