Maternal psychotropic medication and neonatal behavior

Judith G. Auerbach; Sydney L. Hans; Joseph Marcus; Sheila Maeir

doi:10.1016/0892-0362(92)90050-K

Maternal psychotropic medication and neonatal behavior

Judith G. Auerbach, Sydney L. Hans, Joseph Marcus, Sheila Maeir

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Abstract

A sample of 29 psychiatrically ill women and a non-ill comparison group were recruited during pregnancy. Twelve of the ill mothers were receiving antipsychotic and anti-anxiety medication during the final trimester of pregnancy. The behavior of their infants was assessed at 3 and 14 days of age using the Brazelton Neonatal Behavioral Assessment Scale. Compared to infants of non-ill mothers and infants of ill nonmedicated mothers, infants whose mothers received antipsychotic drugs - particularly those in the phenothiazine family - showed a stable pattern of poor neonatal motor functioning that included tremulousness, hypertonicity, and poor motor maturity. It was speculated that this behavior was symptomatic of a neonatal abstinence or withdrawal syndrome.

Original language	English
Pages (from-to)	399-406
Number of pages	8
Journal	Neurotoxicology and Teratology
Volume	14
Issue number	6
DOIs	https://doi.org/10.1016/0892-0362(92)90050-K
State	Published - 1 Jan 1992
Externally published	Yes

Keywords

Antipsychotic drugs
Psychotropic medication
Schizophrenia

ASJC Scopus subject areas

Toxicology
Developmental Neuroscience
Cellular and Molecular Neuroscience

Access to Document

10.1016/0892-0362(92)90050-K

Cite this

@article{4e16465e892f44e4b22a4b1e125a15d2,

title = "Maternal psychotropic medication and neonatal behavior",

abstract = "A sample of 29 psychiatrically ill women and a non-ill comparison group were recruited during pregnancy. Twelve of the ill mothers were receiving antipsychotic and anti-anxiety medication during the final trimester of pregnancy. The behavior of their infants was assessed at 3 and 14 days of age using the Brazelton Neonatal Behavioral Assessment Scale. Compared to infants of non-ill mothers and infants of ill nonmedicated mothers, infants whose mothers received antipsychotic drugs - particularly those in the phenothiazine family - showed a stable pattern of poor neonatal motor functioning that included tremulousness, hypertonicity, and poor motor maturity. It was speculated that this behavior was symptomatic of a neonatal abstinence or withdrawal syndrome.",

keywords = "Antipsychotic drugs, Psychotropic medication, Schizophrenia",

author = "Auerbach, {Judith G.} and Hans, {Sydney L.} and Joseph Marcus and Sheila Maeir",

note = "Funding Information: Collection of infancy data was supported by grants from the US-Israel Binational ScienceF oundation (Grant 598), the Chief Scientist's Office of the Israel Ministry of Health, and the Olivetti Foundation. Funding Information: Analysis of data was supported by a grant from the Scottish Rite Schizophrenia Research Program.",

year = "1992",

month = jan,

day = "1",

doi = "10.1016/0892-0362(92)90050-K",

language = "English",

volume = "14",

pages = "399--406",

journal = "Neurotoxicology and Teratology",

issn = "0892-0362",

publisher = "Elsevier Inc.",

number = "6",

}

TY - JOUR

T1 - Maternal psychotropic medication and neonatal behavior

AU - Auerbach, Judith G.

AU - Hans, Sydney L.

AU - Marcus, Joseph

AU - Maeir, Sheila

N1 - Funding Information: Collection of infancy data was supported by grants from the US-Israel Binational ScienceF oundation (Grant 598), the Chief Scientist's Office of the Israel Ministry of Health, and the Olivetti Foundation. Funding Information: Analysis of data was supported by a grant from the Scottish Rite Schizophrenia Research Program.

PY - 1992/1/1

Y1 - 1992/1/1

N2 - A sample of 29 psychiatrically ill women and a non-ill comparison group were recruited during pregnancy. Twelve of the ill mothers were receiving antipsychotic and anti-anxiety medication during the final trimester of pregnancy. The behavior of their infants was assessed at 3 and 14 days of age using the Brazelton Neonatal Behavioral Assessment Scale. Compared to infants of non-ill mothers and infants of ill nonmedicated mothers, infants whose mothers received antipsychotic drugs - particularly those in the phenothiazine family - showed a stable pattern of poor neonatal motor functioning that included tremulousness, hypertonicity, and poor motor maturity. It was speculated that this behavior was symptomatic of a neonatal abstinence or withdrawal syndrome.

AB - A sample of 29 psychiatrically ill women and a non-ill comparison group were recruited during pregnancy. Twelve of the ill mothers were receiving antipsychotic and anti-anxiety medication during the final trimester of pregnancy. The behavior of their infants was assessed at 3 and 14 days of age using the Brazelton Neonatal Behavioral Assessment Scale. Compared to infants of non-ill mothers and infants of ill nonmedicated mothers, infants whose mothers received antipsychotic drugs - particularly those in the phenothiazine family - showed a stable pattern of poor neonatal motor functioning that included tremulousness, hypertonicity, and poor motor maturity. It was speculated that this behavior was symptomatic of a neonatal abstinence or withdrawal syndrome.

KW - Antipsychotic drugs

KW - Psychotropic medication

KW - Schizophrenia

UR - http://www.scopus.com/inward/record.url?scp=0026677476&partnerID=8YFLogxK

U2 - 10.1016/0892-0362(92)90050-K

DO - 10.1016/0892-0362(92)90050-K

M3 - Article

AN - SCOPUS:0026677476

VL - 14

SP - 399

EP - 406

JO - Neurotoxicology and Teratology

JF - Neurotoxicology and Teratology

SN - 0892-0362

IS - 6

ER -

Maternal psychotropic medication and neonatal behavior

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this