Maternal serum concentrations of the chemokine CXCL10/IP-10 are elevated in acute pyelonephritis during pregnancy

Francesca Gotsch, Roberto Romero, Jimmy Espinoza, Juan Pedro Kusanovic, Shali Mazaki-Tovi, Offer Erez, Nandor Gabor Than, Samuel Edwin, Moshe Mazor, Bo Hyan Yoon, Sonia S. Hassan

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Objective. Acute pyelonephritis is one of the most frequent medical complications of pregnancy, as well as a common cause of antepartum hospitalization. Interferon (IFN)-γ inducible protein, CXCL10/IP-10, is a member of the CXC chemokine family with pro-inflammatory and anti-angiogenic properties. The purpose of this study was to determine whether maternal serum concentrations of CXCL10/IP-10 change in patients with acute pyelonephritis during pregnancy. Study design. This cross-sectional study was conducted to determine the difference in maternal serum concentrations of CXCL10/IP-10 in pregnant women with acute pyelonephritis (N = 41) and normal pregnant women (N = 89). Pyelonephritis was defined in the presence of a positive urine culture, fever, and maternal clinical signs; blood cultures were performed in 36 cases. Maternal serum concentrations of CXCL10/IP-10 were measured by a sensitive immunoassay. Non-parametric statistics were used for analysis. Results. (1) The median serum concentration of CXCL10/IP-10 in pregnant patients with pyelonephritis was significantly higher than in normal pregnant women (median 318.5 pg/mL, range 78.8-2459.2 vs. median 116.1 pg/mL, range 40.7-1314.3, respectively; p < 0.001); (2) maternal median serum concentrations of CXCL10/IP-10 did not differ significantly among patients with acute pyelonephritis with and without bacteremia (positive blood cultures: median 362.6 pg/mL, range 100.2-2459.2 vs. negative blood cultures: median 298.9 pg/mL, range 108.5-1148.7, respectively; p = 0.3). Conclusions. Pyelonephritis in pregnant women is associated with an increased maternal serum concentration of the chemokine CXCL10/IP-10.

Original languageEnglish
Pages (from-to)735-744
Number of pages10
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume20
Issue number10
DOIs
StatePublished - 6 Sep 2007
Externally publishedYes

Keywords

  • CXCL10
  • Chemokines
  • Chemotactic chemokine
  • IP-10
  • Maternal infection
  • Pregnancy
  • Respiratory distress syndrome
  • Serum
  • Urinary infection

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