Maternal Systemic Lupus Erythematosus (SLE) High Risk for Preterm Delivery and Not for Long-Term Neurological Morbidity of the Offspring

Dora Davidov, Eyal Sheiner, Tamar Wainstock, Shayna Miodownik, Gali Pariente

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

OBJECTIVE: Pregnancies of women with systemic lupus erythematosus (SLE) are associated with preterm delivery. As preterm delivery is associated with long-term neurological morbidity, we opted to evaluate the long-term neurologic outcomes of offspring born to mothers with SLE regardless of gestational age.

METHODS: Perinatal outcomes and long-term neurological disease of children of women with and without SLE during pregnancy were evaluated. Children of women with and without SLE were followed until 18 years of age for neurological diseases. Generalized estimating equation (GEE) models were used to assess perinatal outcomes. To compare cumulative neurological morbidity incidence a Kaplan-Meier survival curve was used, and a Cox proportional hazards model was used to control for confounders.

RESULT: A total of 243,682 deliveries were included, of which 100 (0.041%) were of women with SLE. Using a GEE model, maternal SLE was noted as an independent risk factor for preterm delivery. The cumulative incidence of long-term neurological disease was not found to be significantly higher when using the Kaplan Meier survival curves and maternal SLE was not found to be associated with long-term neurological disease of the offspring when a Cox model was used.

CONCLUSION: Despite the association of SLE with preterm delivery, no difference in long-term neurological disease was found among children of women with or without SLE.

Original languageEnglish
Article number2952
Number of pages8
JournalJournal of Clinical Medicine
Volume10
Issue number13
DOIs
StatePublished - 30 Jun 2021

Keywords

  • Neurologic morbidity
  • Offspring
  • Preterm delivery
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • General Medicine

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