Matrices of acidic β-sheet peptides as templates for calcium phosphate mineralization

Shlomit Segman-Magidovich; Haviv Grisaru; Tamar Gitli; Yael Levi-Kalisman; Hanna Rapaport

doi:10.1002/adma.200702125

Matrices of acidic β-sheet peptides as templates for calcium phosphate mineralization

Shlomit Segman-Magidovich, Haviv Grisaru, Tamar Gitli, Yael Levi-Kalisman, Hanna Rapaport

Department of Biotechnology Engineering

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

Early stage of calcium phosphate mineralization on designed β-sheet peptides was monitored that may serve as nucleating templates for hydroxyapatite. A solution composed of the various ions present in the blood serum, in 1.5× their physiological concentration, was selected to monitor the mineralization under conditions that may be of biological relevancy. A film of the peptide that is spread on SBF_1.5 and held 18 hrs in the expanded state prior to compression, becomes less compressible. The TEM images showed structural features that are nanomeric in scale, and found that the flat calcium phosphate sheets could be a form of unchanged amorphous calcium phosphate aggregates. The 20 days mineralized peptide film shows the most prominent differences between the 20 days and 10 days spectra with an enhanced absorption at 1037 cm^-1.

Original language	English
Pages (from-to)	2156-2161
Number of pages	6
Journal	Advanced Materials
Volume	20
Issue number	11
DOIs	https://doi.org/10.1002/adma.200702125
State	Published - 4 Jun 2008

ASJC Scopus subject areas

General Materials Science
Mechanics of Materials
Mechanical Engineering

Access to Document

10.1002/adma.200702125

Cite this

@article{7027e90b96614d0abac978cce18921a6,

title = "Matrices of acidic β-sheet peptides as templates for calcium phosphate mineralization",

abstract = "Early stage of calcium phosphate mineralization on designed β-sheet peptides was monitored that may serve as nucleating templates for hydroxyapatite. A solution composed of the various ions present in the blood serum, in 1.5× their physiological concentration, was selected to monitor the mineralization under conditions that may be of biological relevancy. A film of the peptide that is spread on SBF1.5 and held 18 hrs in the expanded state prior to compression, becomes less compressible. The TEM images showed structural features that are nanomeric in scale, and found that the flat calcium phosphate sheets could be a form of unchanged amorphous calcium phosphate aggregates. The 20 days mineralized peptide film shows the most prominent differences between the 20 days and 10 days spectra with an enhanced absorption at 1037 cm-1.",

author = "Shlomit Segman-Magidovich and Haviv Grisaru and Tamar Gitli and Yael Levi-Kalisman and Hanna Rapaport",

year = "2008",

month = jun,

day = "4",

doi = "10.1002/adma.200702125",

language = "English",

volume = "20",

pages = "2156--2161",

journal = "Advanced Materials",

issn = "0935-9648",

publisher = "Wiley-Blackwell",

number = "11",

}

TY - JOUR

T1 - Matrices of acidic β-sheet peptides as templates for calcium phosphate mineralization

AU - Segman-Magidovich, Shlomit

AU - Grisaru, Haviv

AU - Gitli, Tamar

AU - Levi-Kalisman, Yael

AU - Rapaport, Hanna

PY - 2008/6/4

Y1 - 2008/6/4

N2 - Early stage of calcium phosphate mineralization on designed β-sheet peptides was monitored that may serve as nucleating templates for hydroxyapatite. A solution composed of the various ions present in the blood serum, in 1.5× their physiological concentration, was selected to monitor the mineralization under conditions that may be of biological relevancy. A film of the peptide that is spread on SBF1.5 and held 18 hrs in the expanded state prior to compression, becomes less compressible. The TEM images showed structural features that are nanomeric in scale, and found that the flat calcium phosphate sheets could be a form of unchanged amorphous calcium phosphate aggregates. The 20 days mineralized peptide film shows the most prominent differences between the 20 days and 10 days spectra with an enhanced absorption at 1037 cm-1.

AB - Early stage of calcium phosphate mineralization on designed β-sheet peptides was monitored that may serve as nucleating templates for hydroxyapatite. A solution composed of the various ions present in the blood serum, in 1.5× their physiological concentration, was selected to monitor the mineralization under conditions that may be of biological relevancy. A film of the peptide that is spread on SBF1.5 and held 18 hrs in the expanded state prior to compression, becomes less compressible. The TEM images showed structural features that are nanomeric in scale, and found that the flat calcium phosphate sheets could be a form of unchanged amorphous calcium phosphate aggregates. The 20 days mineralized peptide film shows the most prominent differences between the 20 days and 10 days spectra with an enhanced absorption at 1037 cm-1.

UR - http://www.scopus.com/inward/record.url?scp=55049134411&partnerID=8YFLogxK

U2 - 10.1002/adma.200702125

DO - 10.1002/adma.200702125

M3 - Article

AN - SCOPUS:55049134411

SN - 0935-9648

VL - 20

SP - 2156

EP - 2161

JO - Advanced Materials

JF - Advanced Materials

IS - 11

ER -

Matrices of acidic β-sheet peptides as templates for calcium phosphate mineralization

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this