Meaning-making in the immune system

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations


Meaning-making is the process by which a system responds to an indeterminate signal. This article focuses on meaning-making in living systems. It proposes several guidelines for studying the process of meaning-making in living systems in general, and in the immune system in particular. Drawing on a general framework for studying meaning-making in living systems, I suggest three basic organizing concepts for studying meaning-making - variability of the signal, context markers, and transgradience. Those concepts present a radical alternative to the information-processing approach that governs biological research and may shed new light on biological processes.

Original languageEnglish
Pages (from-to)317-327
Number of pages11
JournalPerspectives in Biology and Medicine
Issue number3
StatePublished - 1 Jan 2004

ASJC Scopus subject areas

  • Issues, ethics and legal aspects
  • Health Policy
  • History and Philosophy of Science


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