Measuring Mitochondrial Uncoupling in Mouse Primary Brown Adipocytes Differentiated Ex Vivo

Michaela Veliova, Marcus J. Tol, Peter Tontonoz, Orian S. Shirihai, Marc Liesa

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Measuring the mitochondrial respiratory capacity of brown adipocytes ex vivo is an essential approach to understand the cell-autonomous regulators of mitochondrial uncoupling in brown adipose tissue. Here, we describe two protocols to isolate brown preadipocytes from mice, their ex vivo differentiation to mature brown adipocytes and the quantification of their mitochondrial uncoupling capacity by respirometry.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages53-65
Number of pages13
DOIs
StatePublished - 1 Jan 2023
Externally publishedYes

Publication series

NameMethods in Molecular Biology
Volume2662
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Keywords

  • Brown adipocytes
  • Mitochondria
  • Respirometry
  • Thermogenesis
  • Uncoupling

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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