Measuring the effect of Mankai® (Wolffia globosa) on the gut microbiota and its metabolic output using an in vitro colon model

Camilla Diotallevi, Giulia Gaudioso, Francesca Fava, Andrea Angeli, Cesare Lotti, Urska Vrhovsek, Ehud Rinott, Iris Shai, Marco Gobbetti, Kieran Tuohy

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Mankai® is a cultivated strain of Wolffia globosa an aquatic plant of the family Lemnaceae commonly known as Duckweeds. Recent studies suggest that consumption of a Mankai® enriched diet may provide positive health effects by decreasing body weight and improving glucose homeostasis and plasma lipid profiles. However, the effects of Mankai® alone on the composition and metabolic output of the human gut microbiota has not been fully investigated. Here, Mankai® was digested and fermented in vitro using a batch culture model of the proximal colon. Inulin and cellulose were used as readily and poorly fermentable control fibers respectively. Mankai® significantly stimulated the production of phenolic metabolites and short chain fatty acids by the gut microbiota (p<0.05). Three major microbial metabolites, 3-4-hydroxyphenyl propionic acid, 3-3-hydroxyphenyl propanoic acid and protocatechuic acid were significantly increased after 24 h fermentation. Moreover, Mankai® treatment lowered the overall microbial diversity (p<0.05), in line with a selective microbiome modulation.

Original languageEnglish
Article number104597
JournalJournal of Functional Foods
Volume84
DOIs
StatePublished - 1 Sep 2021

Keywords

  • Batch culture
  • Mankai®
  • Microbiota
  • Polyphenols
  • Short chain fatty acids
  • Wolffia globosa

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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