Mechanical ventilation for older medical patients in a large tertiary medical care center

Bella Smolin, Ayelet Raz-Pasteur, Tatiana Mashiach, Hisam Zaidani, Leon Levi, Alexander Strizevsky, Daniel A. King, Tzvi Dwolatzky

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Background: The development of technologies for the prolongation of life has resulted in an increase in the number of older ventilated patients in internal medicine and chronic care wards. Our study aimed to determine the factors influencing the outcomes of older ventilated medical patients in a large tertiary medical center. Methods: We performed a prospective observational cohort study including all newly ventilated medical patients aged 65 years and older over a period of 18 months. Data were acquired from computerized medical records and from an interview of the medical personnel initiating mechanical ventilation. Results: A total of 554 patients underwent mechanical ventilation for the first time during the study period. The average age was 79 years, and 80% resided at home. Following mechanical ventilation, 8% died in the emergency room, and the majority of patients (351; 63%) were hospitalized in internal medicine wards. In-hospital mortality was 64.1%, with 48% dying during the first week of hospitalization. Overall 6-months survival was 26%. We found that a combination of age 85 years and older, functional status prior to ventilation, and associated morbidity (diabetes with target organ injury and/or oncological solid organ disease) were the strongest negative predictors of survival after discharge from the hospital. Conclusion: Mechanical ventilation at older age is associated with poor survival and it is possible to identify factors predicting survival. In the midst of the COVID-19 pandemic, the findings of this study may help in the decision-making process regarding mechanical ventilation for older people.

Original languageEnglish
Pages (from-to)253-265
Number of pages13
JournalEuropean Geriatric Medicine
Issue number1
StatePublished - 1 Feb 2022
Externally publishedYes


  • Aging
  • Internal medicine
  • Mechanical ventilation
  • Survival

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Gerontology


Dive into the research topics of 'Mechanical ventilation for older medical patients in a large tertiary medical care center'. Together they form a unique fingerprint.

Cite this