Mechanism of Hyponatremia in Community-Acquired Pneumonia: Does B-Type Natriuretic Peptide Play a Causative Role?

Moran Hausman-Kedem, Shimon Reif, Dana Danino, Rona Limor, Zachary M. Grinspan, Anat Yerushalmi-Feler, Amir Ben-Tov, Amir Birger

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Objective Hyponatremia is a well-known sequela of community-Acquired pneumonia (CAP). B-Type natriuretic peptide (BNP) has a natriuretic effect and was found to be elevated in patients with CAP. We investigated whether BNP has a role in the pathophysiology of hyponatremia in pediatric CAP. Methods Serum and urine electrolytes and osmolality, as well as NT-pro-BNP (N-BNP), were obtained in 49 hospitalized pediatric patients with CAP (29 with hyponatremia, 20 with normal sodium levels. Results Urine sodium levels were lower in the hyponatremic group compared with the normonatremic group (24.3 meq/L vs 66.7 meq/L, P = 0.006). No difference in N-BNP levels was found between groups (median, 103.8 vs 100.1; P = 0.06; interquartile range, 63.7-263.3 pg/mL vs 47.4-146.4 pg/mL). N-BNP was not associated with serum or urinary sodium levels. Conclusions These results indicate that BNP is unlikely to play a causative role in the mechanism of hyponatremia in CAP.

Original languageEnglish
Pages (from-to)641-646
Number of pages6
JournalPediatric Emergency Care
Volume34
Issue number9
DOIs
StatePublished - 1 Sep 2018
Externally publishedYes

Keywords

  • N-BNP
  • community-Acquired pneumonia
  • hyponatremia
  • natriuretic peptides

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Emergency Medicine

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