Susceptibility of adult mice to i.p. infection with HSV 1 was greatly increased by administration of a single dose of cyclophosphamide. Mortality of cyclophosphamide treated virus infected mice was associated with increased virus replication and pathologic changes in brain and liver. The development of a fatal infection in immunosuppressed mice could be curtailed after transfer of specifically immune spleen cells. Passively transferred antibody had no such effect. Protective activity of spleen cells was significantly reduced after pretreatment with anti theta serum. Significant protection was also achieved when normal spleen cells plus immune serum were administered simultaneously. These results indicate that protection against this virus infection is predominantly T cell dependent cell mediated protection may also be operative in vivo.
|Number of pages||6|
|Journal||Journal of Immunology|
|State||Published - 1 Dec 1976|