Mechanism of increased renal tubular sodium reabsorption in cirrhosis

C. Chaimovitz, P. Szylman, G. Alroy, O. S. Better

    Research output: Contribution to journalArticlepeer-review

    45 Scopus citations


    Renal sodium excretion and solute free water clearance were examined during hypotonic saline diuresis in four patients with cirrhosis and ascites and in four normal subjects. (CH2O + CMa) CIn was used as an index of fractional distal tubule sodium load and CH2O CH2O + CNa × 100 as the per cent of this load reabsorbed at the distal tubule. The results demonstrate that the distal sodium supply is similar in both groups and that fractional sodium reabsorption is enhanced at the water clearing segment of the nephron. On the basis of the present data we suggest that sodium retention in some cirrhotic patients, accumulating edema and ascites result from an increase in distal tubular fractional sodium reabsorption.

    Original languageEnglish
    Pages (from-to)198-202
    Number of pages5
    JournalAmerican Journal of Medicine
    Issue number2
    StatePublished - 1 Jan 1972

    ASJC Scopus subject areas

    • General Medicine


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