Mechanism of increased renal tubular sodium reabsorption in cirrhosis

C. Chaimovitz; P. Szylman; G. Alroy; O. S. Better

doi:10.1016/0002-9343(72)90069-1

Mechanism of increased renal tubular sodium reabsorption in cirrhosis

C. Chaimovitz, P. Szylman, G. Alroy, O. S. Better

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Abstract

Renal sodium excretion and solute free water clearance were examined during hypotonic saline diuresis in four patients with cirrhosis and ascites and in four normal subjects. (C_H₂O + C_Ma) C_In was used as an index of fractional distal tubule sodium load and C_H₂O C_H₂O + C_Na × 100 as the per cent of this load reabsorbed at the distal tubule. The results demonstrate that the distal sodium supply is similar in both groups and that fractional sodium reabsorption is enhanced at the water clearing segment of the nephron. On the basis of the present data we suggest that sodium retention in some cirrhotic patients, accumulating edema and ascites result from an increase in distal tubular fractional sodium reabsorption.

Original language	English
Pages (from-to)	198-202
Number of pages	5
Journal	American Journal of Medicine
Volume	52
Issue number	2
DOIs	https://doi.org/10.1016/0002-9343(72)90069-1
State	Published - 1 Jan 1972

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General Medicine

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title = "Mechanism of increased renal tubular sodium reabsorption in cirrhosis",

abstract = "Renal sodium excretion and solute free water clearance were examined during hypotonic saline diuresis in four patients with cirrhosis and ascites and in four normal subjects. (CH2O + CMa) CIn was used as an index of fractional distal tubule sodium load and CH2O CH2O + CNa × 100 as the per cent of this load reabsorbed at the distal tubule. The results demonstrate that the distal sodium supply is similar in both groups and that fractional sodium reabsorption is enhanced at the water clearing segment of the nephron. On the basis of the present data we suggest that sodium retention in some cirrhotic patients, accumulating edema and ascites result from an increase in distal tubular fractional sodium reabsorption.",

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AU - Chaimovitz, C.

AU - Szylman, P.

AU - Alroy, G.

AU - Better, O. S.

PY - 1972/1/1

Y1 - 1972/1/1

N2 - Renal sodium excretion and solute free water clearance were examined during hypotonic saline diuresis in four patients with cirrhosis and ascites and in four normal subjects. (CH2O + CMa) CIn was used as an index of fractional distal tubule sodium load and CH2O CH2O + CNa × 100 as the per cent of this load reabsorbed at the distal tubule. The results demonstrate that the distal sodium supply is similar in both groups and that fractional sodium reabsorption is enhanced at the water clearing segment of the nephron. On the basis of the present data we suggest that sodium retention in some cirrhotic patients, accumulating edema and ascites result from an increase in distal tubular fractional sodium reabsorption.

AB - Renal sodium excretion and solute free water clearance were examined during hypotonic saline diuresis in four patients with cirrhosis and ascites and in four normal subjects. (CH2O + CMa) CIn was used as an index of fractional distal tubule sodium load and CH2O CH2O + CNa × 100 as the per cent of this load reabsorbed at the distal tubule. The results demonstrate that the distal sodium supply is similar in both groups and that fractional sodium reabsorption is enhanced at the water clearing segment of the nephron. On the basis of the present data we suggest that sodium retention in some cirrhotic patients, accumulating edema and ascites result from an increase in distal tubular fractional sodium reabsorption.

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Mechanism of increased renal tubular sodium reabsorption in cirrhosis

Abstract

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