Mechanism of lithium lethality in rats

Yuly Bersudsky; Ilya Vinnitsky; Diana Ghelber; Ora Kofman; Zev Kaplan; R. H. Belmaker

doi:10.1016/0022-3956(93)90068-D

Mechanism of lithium lethality in rats

Yuly Bersudsky
, Ilya Vinnitsky
, Diana Ghelber
, Ora Kofman
, Zev Kaplan
, R. H. Belmaker

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Lithium inhibits inositol monophosphatase and thereby lowers inositol levels and raises inositol-1-phosphate levels. Many of lithium's biological effects are reversible by inositol replacement. However, lethality caused by high dose lithium was not found to be reversible by intracerebroventricular inositol in various dosages or schedules. Moreover, inositol-1-phosphate, given alone or in the presence of sublethal Li doses to inhibit its degradation, did not show toxic or lethal effects. Therefore inositol depletion or inositol-1-phosphate accumulation are probably not related to lithium lethality.

Original language	English
Pages (from-to)	415-422
Number of pages	8
Journal	Journal of Psychiatric Research
Volume	27
Issue number	4
DOIs	https://doi.org/10.1016/0022-3956(93)90068-D
State	Published - 1 Jan 1993

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/0022-3956(93)90068-D

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title = "Mechanism of lithium lethality in rats",

abstract = "Lithium inhibits inositol monophosphatase and thereby lowers inositol levels and raises inositol-1-phosphate levels. Many of lithium's biological effects are reversible by inositol replacement. However, lethality caused by high dose lithium was not found to be reversible by intracerebroventricular inositol in various dosages or schedules. Moreover, inositol-1-phosphate, given alone or in the presence of sublethal Li doses to inhibit its degradation, did not show toxic or lethal effects. Therefore inositol depletion or inositol-1-phosphate accumulation are probably not related to lithium lethality.",

author = "Yuly Bersudsky and Ilya Vinnitsky and Diana Ghelber and Ora Kofman and Zev Kaplan and Belmaker, \{R. H.\}",

year = "1993",

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T1 - Mechanism of lithium lethality in rats

AU - Bersudsky, Yuly

AU - Vinnitsky, Ilya

AU - Ghelber, Diana

AU - Kofman, Ora

AU - Kaplan, Zev

AU - Belmaker, R. H.

PY - 1993/1/1

Y1 - 1993/1/1

N2 - Lithium inhibits inositol monophosphatase and thereby lowers inositol levels and raises inositol-1-phosphate levels. Many of lithium's biological effects are reversible by inositol replacement. However, lethality caused by high dose lithium was not found to be reversible by intracerebroventricular inositol in various dosages or schedules. Moreover, inositol-1-phosphate, given alone or in the presence of sublethal Li doses to inhibit its degradation, did not show toxic or lethal effects. Therefore inositol depletion or inositol-1-phosphate accumulation are probably not related to lithium lethality.

AB - Lithium inhibits inositol monophosphatase and thereby lowers inositol levels and raises inositol-1-phosphate levels. Many of lithium's biological effects are reversible by inositol replacement. However, lethality caused by high dose lithium was not found to be reversible by intracerebroventricular inositol in various dosages or schedules. Moreover, inositol-1-phosphate, given alone or in the presence of sublethal Li doses to inhibit its degradation, did not show toxic or lethal effects. Therefore inositol depletion or inositol-1-phosphate accumulation are probably not related to lithium lethality.

UR - https://www.scopus.com/pages/publications/0027858202

U2 - 10.1016/0022-3956(93)90068-D

DO - 10.1016/0022-3956(93)90068-D

M3 - Article

AN - SCOPUS:0027858202

SN - 0022-3956

VL - 27

SP - 415

EP - 422

JO - Journal of Psychiatric Research

JF - Journal of Psychiatric Research

IS - 4

ER -

Mechanism of lithium lethality in rats

Abstract

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