Mechanism of reaction of peroxomethyl radicals with copper(II)(glycine) 2 and copper(II)(glycylglycylglycine) in aqueous solutions

Corin Mansano-Weiss; Alexandra Masarwa; Haim Cohen; Dan Meyerstein

doi:10.1016/j.ica.2005.02.004

Mechanism of reaction of peroxomethyl radicals with copper(II)(glycine) ₂ and copper(II)(glycylglycylglycine) in aqueous solutions

Corin Mansano-Weiss, Alexandra Masarwa, Haim Cohen, Dan Meyerstein

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The reactions of •O₂CH₃ radicals with Cu ^II(glycine)₂ and Cu^II(GGG), GGG = glycylglycylglycine, in aqueous solutions were studied. The results demonstrate that the peroxyl radicals oxidize the copper complexes forming relatively stable intermediates of the type L_mCu^III-OOCH₃. These intermediates decompose via oxidation of the ligands glycine and GGG, respectively. Substituents on the alkyl of the peroxyl radical affect somewhat the kinetics of reaction but not the mechanism of oxidation. It is suggested that analogous reactions are probably contributing to the radical-induced deleterious biological processes.

Original language	English
Pages (from-to)	2199-2206
Number of pages	8
Journal	Inorganica Chimica Acta
Volume	358
Issue number	7
DOIs	https://doi.org/10.1016/j.ica.2005.02.004
State	Published - 15 Apr 2005

Keywords

Biological ligands
Copper complexes
Peroxyl radicals

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Inorganic Chemistry
Materials Chemistry

Access to Document

10.1016/j.ica.2005.02.004

Cite this

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title = "Mechanism of reaction of peroxomethyl radicals with copper(II)(glycine) 2 and copper(II)(glycylglycylglycine) in aqueous solutions",

abstract = "The reactions of •O2CH3 radicals with Cu II(glycine)2 and CuII(GGG), GGG = glycylglycylglycine, in aqueous solutions were studied. The results demonstrate that the peroxyl radicals oxidize the copper complexes forming relatively stable intermediates of the type LmCuIII-OOCH3. These intermediates decompose via oxidation of the ligands glycine and GGG, respectively. Substituents on the alkyl of the peroxyl radical affect somewhat the kinetics of reaction but not the mechanism of oxidation. It is suggested that analogous reactions are probably contributing to the radical-induced deleterious biological processes.",

keywords = "Biological ligands, Copper complexes, Peroxyl radicals",

author = "Corin Mansano-Weiss and Alexandra Masarwa and Haim Cohen and Dan Meyerstein",

note = "Funding Information: This study was supported in part by grants from the Israel Science Foundation and from the Budgeting and Planning Committee of The Council of Higher Education and the Israel Atomic Energy Commission. D.M. thanks the Alexander von Humboldt Foundation for support and Mrs. Irene Evens for her ongoing interest and support.",

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T1 - Mechanism of reaction of peroxomethyl radicals with copper(II)(glycine) 2 and copper(II)(glycylglycylglycine) in aqueous solutions

AU - Mansano-Weiss, Corin

AU - Masarwa, Alexandra

AU - Cohen, Haim

AU - Meyerstein, Dan

N1 - Funding Information: This study was supported in part by grants from the Israel Science Foundation and from the Budgeting and Planning Committee of The Council of Higher Education and the Israel Atomic Energy Commission. D.M. thanks the Alexander von Humboldt Foundation for support and Mrs. Irene Evens for her ongoing interest and support.

PY - 2005/4/15

Y1 - 2005/4/15

N2 - The reactions of •O2CH3 radicals with Cu II(glycine)2 and CuII(GGG), GGG = glycylglycylglycine, in aqueous solutions were studied. The results demonstrate that the peroxyl radicals oxidize the copper complexes forming relatively stable intermediates of the type LmCuIII-OOCH3. These intermediates decompose via oxidation of the ligands glycine and GGG, respectively. Substituents on the alkyl of the peroxyl radical affect somewhat the kinetics of reaction but not the mechanism of oxidation. It is suggested that analogous reactions are probably contributing to the radical-induced deleterious biological processes.

AB - The reactions of •O2CH3 radicals with Cu II(glycine)2 and CuII(GGG), GGG = glycylglycylglycine, in aqueous solutions were studied. The results demonstrate that the peroxyl radicals oxidize the copper complexes forming relatively stable intermediates of the type LmCuIII-OOCH3. These intermediates decompose via oxidation of the ligands glycine and GGG, respectively. Substituents on the alkyl of the peroxyl radical affect somewhat the kinetics of reaction but not the mechanism of oxidation. It is suggested that analogous reactions are probably contributing to the radical-induced deleterious biological processes.

KW - Biological ligands

KW - Copper complexes

KW - Peroxyl radicals

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DO - 10.1016/j.ica.2005.02.004

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JO - Inorganica Chimica Acta

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