Mechanisms by which kinesin‐5 motors perform their multiple intracellular functions

Himanshu Pandey, Mary Popov, Alina Goldstein‐levitin, Larisa Gheber

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


Bipolar kinesin‐5 motor proteins perform multiple intracellular functions, mainly during mitotic cell division. Their specialized structural characteristics enable these motors to perform their essential functions by crosslinking and sliding apart antiparallel microtubules (MTs). In this review, we discuss the specialized structural features of kinesin‐5 motors, and the mechanisms by which these features relate to kinesin‐5 functions and motile properties. In addition, we discuss the multiple roles of the kinesin‐5 motors in dividing as well as in non‐dividing cells, and examine their roles in pathogenetic conditions. We describe the recently discovered bidirectional motility in fungi kinesin‐5 motors, and discuss its possible physiological relevance. Finally, we also focus on the multiple mechanisms of regulation of these unique motor proteins.

Original languageEnglish
Article number6420
JournalInternational Journal of Molecular Sciences
Issue number12
StatePublished - 2 Jun 2021


  • Cell‐cycle regulation of kinesin activity
  • Kinesin‐5
  • Microtubules
  • Mitosis

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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