TY - JOUR
T1 - Mechanisms by which kinesin‐5 motors perform their multiple intracellular functions
AU - Pandey, Himanshu
AU - Popov, Mary
AU - Goldstein‐levitin, Alina
AU - Gheber, Larisa
N1 - Funding Information:
Funding: This work was supported in part by the Israel Science Foundation (ISF) grant 386/18 and the United States—Israel Binational Science Foundation (BSF) grant BSF‐2019008 awarded to L.G.
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/6/2
Y1 - 2021/6/2
N2 - Bipolar kinesin‐5 motor proteins perform multiple intracellular functions, mainly during mitotic cell division. Their specialized structural characteristics enable these motors to perform their essential functions by crosslinking and sliding apart antiparallel microtubules (MTs). In this review, we discuss the specialized structural features of kinesin‐5 motors, and the mechanisms by which these features relate to kinesin‐5 functions and motile properties. In addition, we discuss the multiple roles of the kinesin‐5 motors in dividing as well as in non‐dividing cells, and examine their roles in pathogenetic conditions. We describe the recently discovered bidirectional motility in fungi kinesin‐5 motors, and discuss its possible physiological relevance. Finally, we also focus on the multiple mechanisms of regulation of these unique motor proteins.
AB - Bipolar kinesin‐5 motor proteins perform multiple intracellular functions, mainly during mitotic cell division. Their specialized structural characteristics enable these motors to perform their essential functions by crosslinking and sliding apart antiparallel microtubules (MTs). In this review, we discuss the specialized structural features of kinesin‐5 motors, and the mechanisms by which these features relate to kinesin‐5 functions and motile properties. In addition, we discuss the multiple roles of the kinesin‐5 motors in dividing as well as in non‐dividing cells, and examine their roles in pathogenetic conditions. We describe the recently discovered bidirectional motility in fungi kinesin‐5 motors, and discuss its possible physiological relevance. Finally, we also focus on the multiple mechanisms of regulation of these unique motor proteins.
KW - Cell‐cycle regulation of kinesin activity
KW - Kinesin‐5
KW - Microtubules
KW - Mitosis
UR - http://www.scopus.com/inward/record.url?scp=85107844288&partnerID=8YFLogxK
U2 - 10.3390/ijms22126420
DO - 10.3390/ijms22126420
M3 - Review article
C2 - 34203964
AN - SCOPUS:85107844288
SN - 1661-6596
VL - 22
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 12
M1 - 6420
ER -