Mechanisms of interaction between interferon gamma and antineoplastic agents on growth and differentiation of leukemic cells: A review

A. Dvilansky, M. Kafka, I. Nathan

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

INTRODUCTION Combination chemotherapy is commonly used in the treatment of leukemia. The use of biological response modifiers in combination with chemotherapeutic drugs offers a novel therapeutic combination with increased efficacy and attenuation of toxic side effects. The mechanism of interaction between the various biological modifiers themselves and that of the biological modifiers with chemotherapeutic agents is still not completely clear. Interferon gamma (IFNγ is one of the biological modifiers which exerts both an antiproliferative and differentiating capacity on leukemic cells and also interacts with antileukemic agents in a synergistic manner. Our review summarizes and evaluates the mode of this interaction on leukemic cells.

Original languageEnglish
Pages (from-to)469-477
Number of pages9
JournalLeukemia and Lymphoma
Volume6
Issue number6
DOIs
StatePublished - 1 Jan 1992

Keywords

  • Antineoplastic agents
  • Differentiation
  • Growth
  • Interferon gamma
  • Leukemic cells

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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