Meconium-stained amniotic fluid: A risk factor for microbial invasion of the amniotic cavity

Roberto Romero, Shuichi Hanaoka, Moshe Mazor, Apostolos P. Athanassiadis, Robert Callahan, Yu Chiung Hsu, Cecilia Avila, Jose Nores, Carlos Jimenez

    Research output: Contribution to journalArticlepeer-review

    97 Scopus citations

    Abstract

    The purpose of this study was to determine whether meconium-stained amniotic fluid is a marker for microbial invasion of the amniotic cavity. Amniocentesis was performed on 707 patients presenting with preterm labor and intact membranes. Meconium-stained amniotic fluid was present in 4.2% (30/707) of patients with preterm labor. The prevalence of positive amniotic fluid cultures was significantly higher in women with meconium-stained amniotic fluid than in women with clear fluid (33% [10/30] vs 11% [75/677]; p = 0.001; odds ratio = 4.01; 95% confidence interval = 1.6 to 9.4). Patients with meconium-stained amniotic fluid were also more likely to have failed tocolysis and delivered a preterm neonate more frequently than patients with clear fluid (83% [25/30] vs 38% (258/677); p = 0.0001; odds ratio = 8.1; 95% confidence interval = 2.9 to 24.4). We conclude that meconium-stained amniotic fluid is a risk factor for microbial invasion of the amniotic cavity and preterm delivery in women with preterm labor and intact membranes.

    Original languageEnglish
    Pages (from-to)859-862
    Number of pages4
    JournalAmerican Journal of Obstetrics and Gynecology
    Volume164
    Issue number3
    DOIs
    StatePublished - 1 Jan 1991

    Keywords

    • Listeria monocytogenes
    • Preterm labor
    • amniotic fluid
    • chorioamnionitis
    • discolored amniotic fluid
    • intraamniotic infection
    • meconium
    • parturition
    • prematurity
    • tocolysis

    ASJC Scopus subject areas

    • Obstetrics and Gynecology

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