Medical Cannabis for Pediatric Moderate to Severe Complex Motor Disorders

Stephanie Libzon; Lihi Bar Lev Schleider; Naama Saban; Luda Levit; Yulia Tamari; Ilan Linder; Tally Lerman-Sagie; Lubov Blumkin

doi:10.1177/0883073818773028

Medical Cannabis for Pediatric Moderate to Severe Complex Motor Disorders

Stephanie Libzon, Lihi Bar Lev Schleider, Naama Saban, Luda Levit, Yulia Tamari, Ilan Linder, Tally Lerman-Sagie, Lubov Blumkin

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

A complex motor disorder is a combination of various types of abnormal movements that are associated with impaired quality of life (QOL). Current therapeutic options are limited. We studied the efficacy, safety, and tolerability of medical cannabis in children with complex motor disorder. This pilot study was approved by the institutional ethics committee. Two products of cannabidiol (CBD) enriched 5% oil formulation of cannabis were compared: one with 0.25% δ-9-tetrahydrocannabinol (THC) 20:1 group, the other with 0.83% THC 6:1 group. Patients aged 1 to 17 years (n = 25) with complex motor disorder were enrolled. The assigned medication was administered for 5 months. Significant improvement in spasticity and dystonia, sleep difficulties, pain severity, and QOL was observed in the total study cohort, regardless of treatment assignment. Adverse effects were rare and included worsening of seizures in 2 patients, behavioral changes in 2 and somnolence in 1.

Original language	English
Pages (from-to)	565-571
Number of pages	7
Journal	Journal of Child Neurology
Volume	33
Issue number	9
DOIs	https://doi.org/10.1177/0883073818773028
State	Published - 1 Aug 2018
Externally published	Yes

Keywords

CBD
THC
cannabis
cerebral palsy
dystonia
movement disorders
spasticity

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Clinical Neurology

Access to Document

10.1177/0883073818773028

Cite this

@article{d870a180c80e461f88cba46af277e3eb,

title = "Medical Cannabis for Pediatric Moderate to Severe Complex Motor Disorders",

abstract = "A complex motor disorder is a combination of various types of abnormal movements that are associated with impaired quality of life (QOL). Current therapeutic options are limited. We studied the efficacy, safety, and tolerability of medical cannabis in children with complex motor disorder. This pilot study was approved by the institutional ethics committee. Two products of cannabidiol (CBD) enriched 5% oil formulation of cannabis were compared: one with 0.25% δ-9-tetrahydrocannabinol (THC) 20:1 group, the other with 0.83% THC 6:1 group. Patients aged 1 to 17 years (n = 25) with complex motor disorder were enrolled. The assigned medication was administered for 5 months. Significant improvement in spasticity and dystonia, sleep difficulties, pain severity, and QOL was observed in the total study cohort, regardless of treatment assignment. Adverse effects were rare and included worsening of seizures in 2 patients, behavioral changes in 2 and somnolence in 1.",

keywords = "CBD, THC, cannabis, cerebral palsy, dystonia, movement disorders, spasticity",

author = "Stephanie Libzon and Schleider, {Lihi Bar Lev} and Naama Saban and Luda Levit and Yulia Tamari and Ilan Linder and Tally Lerman-Sagie and Lubov Blumkin",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2018.",

year = "2018",

month = aug,

day = "1",

doi = "10.1177/0883073818773028",

language = "English",

volume = "33",

pages = "565--571",

journal = "Journal of Child Neurology",

issn = "0883-0738",

publisher = "SAGE Publications Inc.",

number = "9",

}

TY - JOUR

T1 - Medical Cannabis for Pediatric Moderate to Severe Complex Motor Disorders

AU - Libzon, Stephanie

AU - Schleider, Lihi Bar Lev

AU - Saban, Naama

AU - Levit, Luda

AU - Tamari, Yulia

AU - Linder, Ilan

AU - Lerman-Sagie, Tally

AU - Blumkin, Lubov

N1 - Publisher Copyright: © The Author(s) 2018.

PY - 2018/8/1

Y1 - 2018/8/1

N2 - A complex motor disorder is a combination of various types of abnormal movements that are associated with impaired quality of life (QOL). Current therapeutic options are limited. We studied the efficacy, safety, and tolerability of medical cannabis in children with complex motor disorder. This pilot study was approved by the institutional ethics committee. Two products of cannabidiol (CBD) enriched 5% oil formulation of cannabis were compared: one with 0.25% δ-9-tetrahydrocannabinol (THC) 20:1 group, the other with 0.83% THC 6:1 group. Patients aged 1 to 17 years (n = 25) with complex motor disorder were enrolled. The assigned medication was administered for 5 months. Significant improvement in spasticity and dystonia, sleep difficulties, pain severity, and QOL was observed in the total study cohort, regardless of treatment assignment. Adverse effects were rare and included worsening of seizures in 2 patients, behavioral changes in 2 and somnolence in 1.

AB - A complex motor disorder is a combination of various types of abnormal movements that are associated with impaired quality of life (QOL). Current therapeutic options are limited. We studied the efficacy, safety, and tolerability of medical cannabis in children with complex motor disorder. This pilot study was approved by the institutional ethics committee. Two products of cannabidiol (CBD) enriched 5% oil formulation of cannabis were compared: one with 0.25% δ-9-tetrahydrocannabinol (THC) 20:1 group, the other with 0.83% THC 6:1 group. Patients aged 1 to 17 years (n = 25) with complex motor disorder were enrolled. The assigned medication was administered for 5 months. Significant improvement in spasticity and dystonia, sleep difficulties, pain severity, and QOL was observed in the total study cohort, regardless of treatment assignment. Adverse effects were rare and included worsening of seizures in 2 patients, behavioral changes in 2 and somnolence in 1.

KW - CBD

KW - THC

KW - cannabis

KW - cerebral palsy

KW - dystonia

KW - movement disorders

KW - spasticity

UR - http://www.scopus.com/inward/record.url?scp=85047382971&partnerID=8YFLogxK

U2 - 10.1177/0883073818773028

DO - 10.1177/0883073818773028

M3 - Article

C2 - 29766748

AN - SCOPUS:85047382971

SN - 0883-0738

VL - 33

SP - 565

EP - 571

JO - Journal of Child Neurology

JF - Journal of Child Neurology

IS - 9

ER -

Medical Cannabis for Pediatric Moderate to Severe Complex Motor Disorders

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this