Megakaryocyte development and platelet production

Varda R. Deutsch, Aaron Tomer

Research output: Contribution to journalReview articlepeer-review

239 Scopus citations


Megakaryocytopoiesis involves the commitment of haematopoietic stem cells, and the proliferation, maturation and terminal differentiation of the megakaryocytic progenitors. Circulating levels of thrombopoietin (TPO), the primary growth-factor for the megakaryocyte (MK) lineage, induce concentration-dependent proliferation and maturation of MK progenitors by binding to the c-Mpl receptor and signalling induction. Decreased platelet turnover rates results in increased concentration of free TPO, enabling the compensatory response of marrow MKs to increased platelet production. C-Mpl activity is orchestrated by a complex cascade of signalling molecules that induces the action of specific transcription factors to drive MK proliferation and maturation. Mature MKs form proplatelet projections that are fragmented into circulating particles. Newly developed thrombopoietic agents operating via c-Mpl receptor may prove useful in supporting platelet production in thrombocytopenic state. Herein, we review the regulation of megakaryocytopoiesis and platelet production in normal and disease state, and the new approaches to thrombopoietic therapy.

Original languageEnglish
Pages (from-to)453-466
Number of pages14
JournalBritish Journal of Haematology
Issue number5
StatePublished - 1 Sep 2006


  • Megakaryocytes
  • Megakaryocytopoiesis
  • Platelet production
  • Platelets
  • Thrombopoietin

ASJC Scopus subject areas

  • Hematology


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