Melkersson-Rosenthal syndrome: The possible role of comorbidities in the etiopathogenesis

Guy Shalom, Lipa Bodner, Sima Halevy

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    Abstract

    BACKGROUND: Melkersson-Rosenthal Syndrome (MRS) is a rare syndrome. Recently, possible association between MRS and psoriasis was reported. Our objective is to evaluate the presence of comorbidities in MRS with a focus on psoriasis-related morbidities. METHODS: We conducted a case-control study consisting of a series of 12 patients with MRS and two groups of age- and gender-matched controls: 30 patients with psoriasis vulgaris and 28 patients with acute contact dermatitis. Acomparative analysis for the prevalence of comorbidities, with a focus on psoriasis-related morbidities, was done. RESULTS: Psoriasis-related morbidities including smoking, obesity, dyslipidemia, hypertension, and diabetes mellitus were recorded in 5 (42%) patients with MRS, compared to 15 (50%) patients with psoriasis and 2 (7%) patients with acute contact dermatitis. The prevalence of psoriasis-related morbidities did not differ significantly between the group of patients with MRS and the group of patients with psoriasis. On the other hand, the difference between the group of patients with MRS and the group of patients with contact dermatitis was statistically significant (P=0.01). CONCLUSIONS: The similar prevalence of psoriasis-related morbidities in MRS and in psoriasis may further support an association between MRS and psoriasis.

    Original languageEnglish
    Pages (from-to)347-351
    Number of pages5
    JournalGiornale Italiano di Dermatologia e Venereologia
    Volume154
    Issue number4
    DOIs
    StatePublished - 1 Jan 2019

    Keywords

    • Comorbidity
    • Melkersson-Rosenthal syndrome
    • Psoriasis
    • Simplexvirus
    • Tongue, fissured

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